ALX1 Antibody, FITC conjugated

Code CSB-PA624031LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ALX1 Polyclonal antibody
Uniprot No.
Target Names
ALX1
Alternative Names
ALX homeobox 1 antibody; ALX homeobox protein 1 antibody; ALX1 antibody; ALX1_HUMAN antibody; CART 1 antibody; CART-1 antibody; CART1 antibody; Cartilage homeoprotein 1 antibody; Cartilage paired class homeoprotein 1 antibody; FND3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human ALX homeobox protein 1 protein (10-304AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival. May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1.
Gene References into Functions
  1. According to our analysis, three proteins, namely aristaless-like homeobox1 isoform X1 (ALX1), major histocompatibility complex polypeptide-related sequence A (MICA), and uncharacterized protein C14orf105 isoform X12 were found to be potential markers for Opisthorchis viverrini (OV)- infection, as they were predominantly found in all OV-infected groups PMID: 29936472
  2. Our study concludes that the splice site variant identified in the ALX1 gene causes mild form of Frontonasal dysplasia. PMID: 27324866
  3. we identify critical roles of ALX1 in lung cancer development and progression PMID: 26722397
  4. Knockdown of the CART1 gene significantly inhibited cell invasion and proliferation and induce cell cycle arrest in S phase. PMID: 27053613
  5. we found that depletion of ALX1 caused a dramatic cell cycle arrest, followed by massive apoptotic cell death, and eventually resulted in a significant decrease in migration and invasion of the osteosarcoma cell line studied. PMID: 25736924
  6. hypermethylation of HIST1H4F, PCDHGB6, NPBWR1, ALX1, and HOXA9 was significantly associated with shorter survival in stage 1 Non-small-cell lung cancer PMID: 24081945
  7. ALX1 upregulated expression of the key EMT regulator Snail (SNAI1) and that it mediated EMT activation and cell invasion by ALX1. PMID: 23288509
  8. Disruption of CART1 (ALX1) causes extreme microphthalmia and severe facial clefting. PMID: 20451171

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Involvement in disease
Frontonasal dysplasia 3 (FND3)
Subcellular Location
Nucleus.
Protein Families
Paired homeobox family
Tissue Specificity
Cartilage and cervix tissue.
Database Links

HGNC: 1494

OMIM: 601527

KEGG: hsa:8092

STRING: 9606.ENSP00000315417

UniGene: Hs.41683

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