AMICA1 Antibody

Datasheet

Code	CSB-PA001668GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q86YT9

Target Names

JAML

Alternative Names

adhesion molecule AMICA antibody; Adhesion molecule interacting with CXADR antigen 1 antibody; adhesion molecule interacts with CXADR antigen 1 antibody; adhesion molecule that interacts with CXADR antigen 1 antibody; AMICA antibody; Amica1 antibody; CREA7-1 antibody; CREA7-4 antibody; Dendritic cell-specific protein CREA7-1 antibody; dendritic-cell specific protein CREA7-1 antibody; dendritic-cell specific protein CREA7-4 antibody; FLJ37080 antibody; Gm638 antibody; JAML1_HUMAN antibody; junctional adhesion molecule antibody; Junctional adhesion molecule-like antibody; Junctional adhesion molecule-like precursor antibody; MGC118814 antibody; MGC118815 antibody; UNQ722/PRO1387 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Human AMICA1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

Gene References into Functions

expressed on leukocytes with a possible role in leukocyte transmigration PMID: 12869515
Integrin activation is required for the dissociation of JAM-L-VLA-4 complexes and the accumulation of functional JAM-L dimers, which indicates that the leukocyte integrin VLA-4 controls JAM-L function in cis by controlling its dimerization state. PMID: 19064666

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).

Protein Families

Immunoglobulin superfamily

Tissue Specificity

Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).

Database Links

HGNC: 19084

OMIM: 609770

KEGG: hsa:120425

STRING: 9606.ENSP00000348635

UniGene: Hs.16291

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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