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AMOTL1 Antibody

Datasheet
Code CSB-PA001678GA01HU
Size $600
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Product Details

Uniprot No.
Q8IY63
Target Names
AMOTL1
Alternative Names
2310010G08Rik antibody; 2310067L22Rik antibody; 4932416D09Rik antibody; AMOL1_HUMAN antibody; Amotl1 antibody; Angiomotin-like protein 1 antibody; FLJ00155 antibody; JEAP antibody; Junction enriched and associated protein antibody; mFLJ00155 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human AMOTL1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.
Gene References into Functions
  1. AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin. PMID: 26806348
  2. phosphorylation-deficient S793Ala mutant of AMOTL1 showed a shorter half-life and conferred resistance to energy-stress-induced YAP inhibition. PMID: 25373897
  3. miR-124 binds AmotL1 3'UTR and down-regulates its expression repressing vasculogenic mimicry and cell motility in cervical cancer cells. PMID: 25218344
  4. These results suggested that IFN-gamma exhibits anti-angiogenesis effects by regulating the expression of TNF-alpha-induced AmotL1 via NFkappaB in emphysema lungs. PMID: 23793505
  5. AmotL1 and ZO-2 are two candidates that could be harnessed to control the oncogenic function of YAP. PMID: 21685940
  6. By yeast two-hybrid screening, angiomotin-like 1 (AmotL1) was identified as a host factor that interacts with the M protein of parainfluenza virus 5 (PIV5). PMID: 19932912

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Subcellular Location
Cell junction, tight junction.
Protein Families
Angiomotin family
Database Links

HGNC: 17811

OMIM: 614657

KEGG: hsa:154810

STRING: 9606.ENSP00000387739

UniGene: Hs.503594

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