AMTN Antibody

Code CSB-PA001685LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA001685LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) AMTN Polyclonal antibody
Uniprot No.
Target Names
AMTN
Alternative Names
Amelotin antibody; Amtn antibody; AMTN_HUMAN antibody; RSTI689 antibody; UNQ689 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Amelotin protein (17-209AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The AMTN Antibody (Product code: CSB-PA001685LA01HU) is Non-conjugated. For AMTN Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA001685LB01HU AMTN Antibody, HRP conjugated ELISA
FITC CSB-PA001685LC01HU AMTN Antibody, FITC conjugated
Biotin CSB-PA001685LD01HU AMTN Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.
Gene References into Functions
  1. TNF-alpha stimulates AMTN gene transcription in human gingival epithelial cells via C/EBP1, C/EBP2, and YY1 elements in the human AMTN gene promoter. PMID: 29282478
  2. Results show that AMTN and KLK4 are not essential for biological processes outside of the dentition or during the secretory stage of amelogenesis. Both KLK4 and AMTN proved to be essential for the maturation of dental enamel, a process that requires the removal of extracellularmatrix proteins and the deposition of ions on the sides of enamel crystallites. PMID: 26620968
  3. This study demonstrates for the first time that AMTN mutations cause non-syndromic human Amelogenesis imperfecta (AI) and explores the human phenotype, comparing it with that of mice with disrupted Amtn function. PMID: 27412008
  4. AMTN has a direct influence on biomineralization by promoting hydroxyapatite mineralization. PMID: 25407797
  5. proinflammatory cytokines induce Amelotin gene transcription and a role for Amelotin in gingival inflammation PMID: 25158173

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Involvement in disease
Amelogenesis imperfecta 3B (AI3B)
Subcellular Location
Secreted.
Protein Families
Amelotin family
Database Links

HGNC: 33188

OMIM: 610912

KEGG: hsa:401138

STRING: 9606.ENSP00000341013

UniGene: Hs.453069

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