Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ANAPC1 Polyclonal antibody

Uniprot No.

Q9H1A4

Target Names

ANAPC1

Alternative Names

ANAPC 1 antibody; Anapc1 antibody; Anaphase promoting complex subunit 1 antibody; anaphase-promoting complex 1 (meiotic checkpoint regulator) antibody; Anaphase-promoting complex subunit 1 antibody; Apc 1 antibody; APC1 antibody; APC1_HUMAN antibody; Cyclosome subunit 1 antibody; MCPR antibody; Meiotic checkpoint regulator antibody; Mitotic checkpoint regulator antibody; Protein Tsg 24 antibody; Protein Tsg24 antibody; Testis-specific gene 24 protein antibody; TSG 24 antibody; TSG24 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from Internal of Human APC1.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:50-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Related Products

Target Background

Function	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Gene References into Functions	Data show that FZR1 (Fzr), a cofactor of the multi-subunit E3 ligase complex anaphase-promoting complex/cyclosome (APC/C), represents a therapeutic target in myeloma. PMID: 27655696 in the Alzheimer's disease (AD)mouse model APP/PS1, lower cdh1 levels were observed in pyramidal neurons in CA1 when compared to age-matched wildtype mice. In this review, we provide a complete list of APC/C substrates that are involved in the nervous system and we discuss their functions. We also summarize recent studies that show neurobiological effects in cdh1 knockout mouse models. PMID: 28505105 cryo-EM structure of an APC/C-Cdh1 complex with Apc1(WD40) deleted showed that the mutant APC/C is locked into an inactive conformation in which the UbcH10-binding site of the catalytic module is inaccessible. Additionally, an EM density for Apc15 is not visible PMID: 27601667 The ABBA-KEN-ABBA amino acid motif cassette holds the Mitotic Checkpoint Complex (MCC) onto the Anaphase-Promoting Complex-Cyclosome (APC/C) by binding the two Cdc20 molecules in the MCC-APC/C complex. PMID: 27939943 findings suggest a tumor suppressor role for APC/C(Cdh1) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma. PMID: 26329581 Human Cytomegalovirus UL21a but not UL97 can disrupt APC/C function, leading to the accumulation of substrates and that UL21a is necessary and sufficient to induce the degradation of APC1, in addition to the previously reported APC4 and APC5. PMID: 25903336 Data indicate that regulation of Rad17 turnover is through the Cdh1/anaphase-promoting complex pathway in breast cancer cells. PMID: 23637229 EYA1 is efficiently degraded during mitotic exit in a ANAPC1-dependent manner and these two proteins physically interact. PMID: 23263983 Single nucleotide polymorhpisms of ANAPC1 were associated with nicotine dependence. PMID: 22377092 Studies indicate that the APC/C is tightly regulated by its co-activators and by the spindle assembly checkpoint. PMID: 21633387 the ability of Emi1 to inhibit APC/C is negatively regulated by CDKs PMID: 21454540 Data demonstrate that PFKFB3 is essential for cell division and that it is regulated by APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP. PMID: 21402913 Studies indicate that APC/C(Cdh1) is required to maintain genomic stability. PMID: 19826416 Cdh1 may function as a component in tumor suppression via proteolysis of Skp2 in colorectal tumorigenesis and may serve as a prognostic marker in colon cancer patients. PMID: 18535175 ANAPC1 methylation was probably not implicated in gastric carcinogenesis PMID: 18622497 Show More Hide All
Protein Families	APC1 family
Database Links	HGNC: 19988 OMIM: 608473 KEGG: hsa:64682 STRING: 9606.ENSP00000339109 UniGene: Hs.436527

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Code	CSB-PA105829
Size	US$297Purchase it in Cusabio online store (only available for customers from the US)
Image	Immunohistochemistry analysis of paraffin-embedded human brain tissue using APC1 antibody.
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ANAPC1 Antibody

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Target Background

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