Your Good Partner in Biology Research
Your Good Partner in Biology Research
| Code | CSB-PA596504 |
| Size | US$299 |
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| Have Questions? | Leave a Message or Start an on-line Chat |
| Uniprot No. | Q9UJX6 | ||||||
| Target Names | ANAPC2 | ||||||
| Alternative Names | anapc2 antibody; Anaphase promoting complex subunit 2 antibody; Anaphase-promoting complex subunit 2 antibody; ANC2_HUMAN antibody; APC2 antibody; Cyclosome subunit 2 antibody; KIAA1406 antibody; OTTHUMP00000022692 antibody; RP11 350O14.5 antibody | ||||||
| Raised in | Rabbit | ||||||
| Species Reactivity | Human,Mouse | ||||||
| Immunogen | Fusion protein of Human ANAPC2 | ||||||
| Immunogen Species | Homo sapiens (Human) | ||||||
| Conjugate | Non-conjugated | ||||||
| Isotype | IgG | ||||||
| Purification Method | Antigen affinity purification | ||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
| Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol | ||||||
| Form | Liquid | ||||||
| Tested Applications | ELISA,IHC | ||||||
| Recommended Dilution |
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| Protocols | ELISA Protocol Immunohistochemistry (IHC) Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.
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| Gene References into Functions |
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| Protein Families | Cullin family |
| Database Links |
HGNC: 19989 OMIM: 606946 KEGG: hsa:29882 STRING: 9606.ENSP00000314004 UniGene: Hs.533262 |
