AP1M1 Antibody

1. found 31 ORF9p interaction partners, among which was AP1M1, the mu subunit of the adaptor protein complex 1 (AP-1). AP-1 is a heterotetramer involved in intracellular vesicle-mediated transport and regulates the shuttling of cargo proteins between endosomes and the trans-Golgi network via clathrin-coated vesicles. PMID: 29793951
2. Acidic clusters act as sorting signals for packaging cargo into clathrin-coated vesicles (CCVs), and also facilitate down-regulation of MHC-I by HIV-1 Nef. The basic patch on micro1 that interacts with the Nef acidic cluster also contributes to the binding of endogenous acidic cluster proteins. PMID: 28743825
3. CNNM4 is sorted to the basolateral membrane by the complementary function of AP-1A and AP-1B PMID: 25449265
4. Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1. PMID: 23678182
5. IRS-1 associates with mu1A of the ubiquitously expressed AP-1 complex through three protein interaction motifs. PMID: 23478262
6. Mu1A binding to the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes. PMID: 22301137
7. AP-1 mu1A is involved in the kAE1 trafficking of kidney alpha-intercalated cells PMID: 20833140
8. These data identify the micro subunit of AP-1 (micro1) as the key target of the MHC-I CD/Nef complex, and they indicate that both Y320 in the MHC-I CD and E62-65 in Nef interact directly with micro1. PMID: 18057255

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HGNC: 13667

OMIM: 603535

KEGG: hsa:8907

STRING: 9606.ENSP00000388996

UniGene: Hs.71040