AP1M1 Antibody

Code CSB-PA001864GA01HU
Size US$685
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Product Details

Uniprot No. Q9BXS5
Target Names AP1M1
Alternative Names Adaptor protein complex AP-1 mu-1 subunit antibody; Adaptor-related protein complex 1 mu-1 subunit antibody; AP-1 complex subunit mu-1 antibody; AP-mu chain family member mu1A antibody; Ap1m1 antibody; AP1M1_HUMAN antibody; AP47 antibody; CLAPM2 antibody; Clathrin adaptor protein AP47 antibody; Clathrin assembly protein complex 1 medium chain 1 antibody; Clathrin assembly protein complex 1 medium chain antibody; Clathrin assembly protein complex AP1 mu subunit antibody; Clathrin coat assembly protein AP47 antibody; Clathrin coat-associated protein AP47 antibody; CLTNM antibody; Golgi adaptor AP 1 47 kDa protein antibody; Golgi adaptor HA1/AP1 adaptin mu-1 subunit antibody; HA1 47 kDa subunit antibody; MU 1A antibody; Mu-adaptin 1 antibody; Mu1A-adaptin antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human AP1M1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Gene References into Functions
  1. found 31 ORF9p interaction partners, among which was AP1M1, the mu subunit of the adaptor protein complex 1 (AP-1). AP-1 is a heterotetramer involved in intracellular vesicle-mediated transport and regulates the shuttling of cargo proteins between endosomes and the trans-Golgi network via clathrin-coated vesicles. PMID: 29793951
  2. Acidic clusters act as sorting signals for packaging cargo into clathrin-coated vesicles (CCVs), and also facilitate down-regulation of MHC-I by HIV-1 Nef. The basic patch on micro1 that interacts with the Nef acidic cluster also contributes to the binding of endogenous acidic cluster proteins. PMID: 28743825
  3. CNNM4 is sorted to the basolateral membrane by the complementary function of AP-1A and AP-1B PMID: 25449265
  4. Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1. PMID: 23678182
  5. IRS-1 associates with mu1A of the ubiquitously expressed AP-1 complex through three protein interaction motifs. PMID: 23478262
  6. Mu1A binding to the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes. PMID: 22301137
  7. AP-1 mu1A is involved in the kAE1 trafficking of kidney alpha-intercalated cells PMID: 20833140
  8. These data identify the micro subunit of AP-1 (micro1) as the key target of the MHC-I CD/Nef complex, and they indicate that both Y320 in the MHC-I CD and E62-65 in Nef interact directly with micro1. PMID: 18057255

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Subcellular Location Golgi apparatus, Cytoplasmic vesicle, clathrin-coated vesicle membrane, Peripheral membrane protein, Cytoplasmic side
Protein Families Adaptor complexes medium subunit family
Database Links

HGNC: 13667

OMIM: 603535

KEGG: hsa:8907

STRING: 9606.ENSP00000388996

UniGene: Hs.71040

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