AP1M1 Antibody

Code CSB-PA001864GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
AP1M1
Alternative Names
Adaptor protein complex AP-1 mu-1 subunit antibody; Adaptor-related protein complex 1 mu-1 subunit antibody; AP-1 complex subunit mu-1 antibody; AP-mu chain family member mu1A antibody; Ap1m1 antibody; AP1M1_HUMAN antibody; AP47 antibody; CLAPM2 antibody; Clathrin adaptor protein AP47 antibody; Clathrin assembly protein complex 1 medium chain 1 antibody; Clathrin assembly protein complex 1 medium chain antibody; Clathrin assembly protein complex AP1 mu subunit antibody; Clathrin coat assembly protein AP47 antibody; Clathrin coat-associated protein AP47 antibody; CLTNM antibody; Golgi adaptor AP 1 47 kDa protein antibody; Golgi adaptor HA1/AP1 adaptin mu-1 subunit antibody; HA1 47 kDa subunit antibody; MU 1A antibody; Mu-adaptin 1 antibody; Mu1A-adaptin antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human AP1M1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Gene References into Functions
  1. found 31 ORF9p interaction partners, among which was AP1M1, the mu subunit of the adaptor protein complex 1 (AP-1). AP-1 is a heterotetramer involved in intracellular vesicle-mediated transport and regulates the shuttling of cargo proteins between endosomes and the trans-Golgi network via clathrin-coated vesicles. PMID: 29793951
  2. Acidic clusters act as sorting signals for packaging cargo into clathrin-coated vesicles (CCVs), and also facilitate down-regulation of MHC-I by HIV-1 Nef. The basic patch on micro1 that interacts with the Nef acidic cluster also contributes to the binding of endogenous acidic cluster proteins. PMID: 28743825
  3. CNNM4 is sorted to the basolateral membrane by the complementary function of AP-1A and AP-1B PMID: 25449265
  4. Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1. PMID: 23678182
  5. IRS-1 associates with mu1A of the ubiquitously expressed AP-1 complex through three protein interaction motifs. PMID: 23478262
  6. Mu1A binding to the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes. PMID: 22301137
  7. AP-1 mu1A is involved in the kAE1 trafficking of kidney alpha-intercalated cells PMID: 20833140
  8. These data identify the micro subunit of AP-1 (micro1) as the key target of the MHC-I CD/Nef complex, and they indicate that both Y320 in the MHC-I CD and E62-65 in Nef interact directly with micro1. PMID: 18057255

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Subcellular Location
Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Protein Families
Adaptor complexes medium subunit family
Database Links

HGNC: 13667

OMIM: 603535

KEGG: hsa:8907

STRING: 9606.ENSP00000388996

UniGene: Hs.71040

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