AP2A1 Antibody

Code CSB-PA001869GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
AP2A1
Alternative Names
100 kDa coated vesicle protein A antibody; Adapter-related protein complex 2 alpha-1 subunit antibody; adapter-related protein complex 2 subunit alpha-1 antibody; Adaptin alpha A antibody; Adaptin alpha antibody; Adaptor protein complex AP 2 alpha 1 subunit antibody; adaptor protein complex AP 2 subunit alpha 1 antibody; Adaptor protein complex AP-2 subunit alpha-1 antibody; Adaptor protein complex AP2 alpha 1 subunit antibody; adaptor protein complex AP2 subunit alpha 1 antibody; Adaptor related protein complex 2 alpha 1 subunit antibody; Adaptor related protein complex AP 2 alpha 1 subunit antibody; Adaptor related protein complex AP2 alpha 1 subunit antibody; ADTAA antibody; Alpha A adaptin antibody; Alpha adaptin A antibody; Alpha-adaptin A antibody; alpha1 adaptin antibody; Alpha1-adaptin antibody; AP 2 alpha antibody; AP 2 complex subunit alpha 1 antibody; AP-2 complex subunit alpha-1 antibody; AP2 complex subunit alpha 1 antibody; AP2-ALPHA antibody; Ap2a1 antibody; AP2A1_HUMAN antibody; CLAPA 1 antibody; CLAPA1 antibody; Clathrin adaptor complex AP2. alpha subunit antibody; Clathrin assembly protein complex 2 alpha A large chain antibody; Clathrin assembly protein complex 2 alpha-A large chain antibody; Clathrin associated / assembly / adaptor protein large alpha 1 antibody; clathrin associated assembly adaptor protein large alpha 1 antibody; clathrin associated/assembly/adaptor protein, large, alpha 1 antibody; Plasma membrane adaptor HA 2/AP 2 adaptin alpha A subunit antibody; Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human AP2A1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
Gene References into Functions
  1. Results revealed thirteen novel splice junctions of previously annotated exons. Consecutive nested PCRs led to the determination of the primary structure of seventy-seven novel AP2A1 transcripts, all of which were shown to comprise at least one premature translation termination codon, thus representing nonsense-mediated mRNA decay candidates. PMID: 30081190
  2. AP-2alpha depletion enhanced apoptosis, demonstrating that disrupting the HIV-1 Nef:AP-2alpha interaction limits Nef-mediated apoptosis. PMID: 28577469
  3. These results lead to a model for the docking of the full AP-2 tetramer to membranes as bound to Nef, such that the cytosolic tail of CD4 is situated to interact with its binding site on Nef. PMID: 24473078
  4. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
  5. AP2alpha negatively regulates HIV-1 replication in the process of nuclear translocation of viral DNA in the cytoplasm or the perinuclear region. PMID: 18178234
  6. nef usurps AP-2 complexes to dysregulate Ii (invariant chain (Ii)/major histocompatibility complex class II) trafficking and potentially interfere with antigen presentation in the context of MHC-II PMID: 18524831

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Subcellular Location
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
Protein Families
Adaptor complexes large subunit family
Tissue Specificity
Expressed in the brain (at protein level). Isoform A: Expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B: Widely expressed in tissues and also in breast cancer and in prostate carcinoma cells.
Database Links

HGNC: 561

OMIM: 601026

KEGG: hsa:160

STRING: 9606.ENSP00000351926

UniGene: Hs.467125

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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