APBA2 Antibody

Code CSB-PA001887GA01HU
Size US$685
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Product Details

Uniprot No. Q99767
Target Names APBA2
Alternative Names Adapter protein X11beta antibody; Amyloid beta A4 precursor protein-binding family A member 2 antibody; APBA2 antibody; APBA2_HUMAN antibody; D15S1518E antibody; HsT16821 antibody; LIN 10 antibody; MGC:14091 antibody; MGC99508 antibody; Mint 2 antibody; Mint-2 antibody; MINT2 antibody; Neuron-specific X11L protein antibody; Neuronal Munc18-1-interacting protein 2 antibody; Phosphotyrosine binding/interacting domain (PTB) bearing protein antibody; X11 beta antibody; X11 like protein antibody; X11l antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Human APBA2
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
Gene References into Functions
  1. These results support the hypothesis that APBA2 gene expression in different areas of Alzheimer's patient's brains. PMID: 28164769
  2. Aberrant MINT2 methylation in body fluids may predict peritoneal micrometastasis for gastric cancer (GC) patients, which is a potential poor prognostic factor in GC. PMID: 24385013
  3. a significant difference was shown for APBA2 gene expression of peripheral lymphocytes between Chinese Han Tourette syndrome (TS) group and healthy controls idicating the APBA2 gene is a promising peripheral blood biomarker that discriminates between patients with TS and healthy subjects PMID: 23076970
  4. Amyloid beta A4 precursor protein-binding family A member 2 contains a potent neuronal promoter whose activity may be regulated by DNA methylation and glucocorticoid receptor [alpha], paired box protein 5. PMID: 22222501
  5. The co-occurrence of two nonsynonymous mutations in both affected siblings in a single family, each transmitted from a different unaffected parent, suggest a role for APBA2 mutations in rare individuals with ASD. PMID: 20029827
  6. APBA2 were genes activated in early endometrial endometrioid carcinoma (stages I-II). PMID: 20015385
  7. X11beta-mediated reduction in cerebral Abeta is associated with cognition and long-term potentiation in Alzheimer's disease APPswe transgenic mice. PMID: 19744962
  8. Interaction of transcriptional coactivators with Mint1 or Mint2 prevents nuclear localization and transactivation of the transduction network mediated by amyloid precursor protein. PMID: 20016085
  9. The APBA2 gene has been found to map to a more telomeric location in chromosome 15q13 than previously found, and is partially duplicated within the broader region located approximately 5 Mb distal to the intact locus. PMID: 12720574
  10. hXB51 isoforms regulate Abeta generation differently, either enhancing it by modifying the association of X11L with APP or suppressing it in an X11L-independent manner PMID: 12780348
  11. This protein, which is a member of the mammalian LIN-10 protein family and a possible regulator of Abeta production, elevated APP and APLP2 phosphorylation PMID: 14970211
  12. Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. PMID: 17989066
  13. Phosphorylation of amino acids Ser236 and Ser238 in the X11L regulatory region are critical for increasing association of X11L and amyloid beta-protein precursor and are conserved in X11, a neuronal X11 family protein, but not in non-neuronal X11L2. PMID: 19222704

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Tissue Specificity Brain.
Database Links

HGNC: 579

OMIM: 602712

KEGG: hsa:321

STRING: 9606.ENSP00000453144

UniGene: Hs.618112

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