APOO Antibody

Code CSB-PA001948LA01HU
Size US$299
Image
  • IHC image of CSB-PA001948LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) APOO Polyclonal antibody
Uniprot No. Q9BUR5
Target Names APOO
Alternative Names 0610008C08Rik antibody; 1110019O03Rik antibody; Apolipoprotein O antibody; APOO antibody; APOO_HUMAN antibody; FAM121B antibody; Family with sequence similarity 121B antibody; MGC130105 antibody; MGC130106 antibody; MGC4825 antibody; My025 antibody; MYO25 antibody; OTTHUMP00000023073 antibody; Protein FAM121B antibody; RP23-272D10.2 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human MICOS complex subunit MIC26 protein (26-198AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function
Gene References into Functions
  1. The human apolipoprotein MIC26 is a bona fide subunit of the MICOS complex. PMID: 25764979
  2. It is likely that apoO participates in fatty acid metabolism and the inflammatory response in HepG2 cells. PMID: 24341743
  3. APOO represents a link between impaired mitochondrial function and cardiomyopathy onset, and targeting APOO-dependent metabolic remodeling has potential as a strategy to adjust heart metabolism and protect the myocardium from impaired contractility. PMID: 24743151
  4. relationships between plasma apoO levels and high-sensitive C-reactive protein (hs-CRP) levels, as well as other lipid parameters in healthy subjects and patients with established acute coronary syndrome PMID: 22693255
  5. apolipoprotein O is the first chondroitin sulfate chain containing apolipoprotein PMID: 16956892

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Subcellular Location Mitochondrion inner membrane, Single-pass membrane protein, Secreted, Mitochondrion, Golgi apparatus membrane, Endoplasmic reticulum membrane
Protein Families Apolipoprotein O/MICOS complex subunit Mic27 family
Tissue Specificity Expressed in all tissues examined. Up-regulated in diabetic heart.
Database Links

HGNC: 28727

OMIM: 300753

KEGG: hsa:79135

STRING: 9606.ENSP00000368528

UniGene: Hs.495851

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