ARHGEF3 Antibody

Datasheet

Code	CSB-PA878863ESR2HU
Size	US$166
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Image	Western blot All lanes: ARHGEF3 antibody at 2.21µg/ml Lane 1: MCF-7 whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: Hela whole cell lysate Lane 5: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 60, 64, 61, 37 kDa Observed band size: 60 kDa Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA878863ESR2HU at dilution of 1:100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ARHGEF3 Polyclonal antibody

Uniprot No.

Q9NR81

Target Names

ARHGEF3

Alternative Names

ARHGEF3 antibody; Rho guanine nucleotide exchange factor 3 antibody; Exchange factor found in platelets and leukemic and neuronal tissues antibody; XPLN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Rho guanine nucleotide exchange factor 3 protein (287-526AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.

Gene References into Functions

This is the first study describing the involvement of XPLN in the regulation of the mTORC2-SPARC axis, and these findings may help uncover regulatory mechanisms mediated by XPLN in idiopathic pulmonary fibrosis PMID: 28315487
Our findings suggest that increased expression of ARHGEF3 plays a critical oncogenic role in nasopharyngeal carcinoma pathogenesis PMID: 27028992
Data suggest that modulation of ARHGEF3 gene expression in humans with a promoter-localized SNP plays a role in human megakaryocytes and human platelet function-a finding resulting from the biological follow-up of human genetic studies. Arhgef3 KO mice partially recapitulate the human phenotype. PMID: 28542600
ARHGEF3 has a crucial role in myeloid differentiation. PMID: 25494542
ARHGEF3 and RHOA are potential regulators of a number of genes in bone cells, with influences on ACTA2 evident in both osteoblast-like and osteoclast-like cells. PMID: 24840563
XPLN is an endogenous inhibitor of mTORC2. PMID: 24043828
the association between rs7646054 in ARHGEF3 and bone mineral density observed in Caucasians was not replicated in the chinese samples. PMID: 19727905
a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC PMID: 12221096
genetic variation in ARHGEF3 plays a role in the determination of bone density in Caucasian women. This data implicates the RhoGTPase-RhoGEF pathway in osteoporosis. PMID: 18499081

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Subcellular Location

Cytoplasm.

Tissue Specificity

Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.

Database Links

HGNC: 683

OMIM: 612115

KEGG: hsa:50650

STRING: 9606.ENSP00000341071

UniGene: Hs.476402

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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