ARRDC1 Antibody

Code CSB-PA850807LA01HU
Size US$166
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Image
  • IHC image of CSB-PA850807LA01HU diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA850807LA01HU diluted at 1:400 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of MCF-7 cells with CSB-PA850807LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ARRDC1 Polyclonal antibody
Uniprot No.
Target Names
ARRDC1
Alternative Names
ARRD1_HUMAN antibody; ARRDC 1 antibody; ARRDC1 antibody; Arrestin domain containing 1 antibody; Arrestin domain containing protein 1 antibody; Arrestin domain-containing protein 1 antibody; MGC40555 antibody; OTTHUMP00000022707 antibody; OTTHUMP00000022709 antibody; RP11-48C7.5 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Arrestin domain-containing protein 1 protein (288-433AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ARRDC1 Antibody (Product code: CSB-PA850807LA01HU) is Non-conjugated. For ARRDC1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA850807LB01HU ARRDC1 Antibody, HRP conjugated ELISA
FITC CSB-PA850807LC01HU ARRDC1 Antibody, FITC conjugated
Biotin CSB-PA850807LD01HU ARRDC1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles. More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles. By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway.
Gene References into Functions
  1. The authors show that WWP1 changes the ubiquitination status of ARRDC1, suggesting that the arrestins may provide a platform for ubiquitination in PPXY-dependent budding. PMID: 21191027
Subcellular Location
Cell membrane.
Protein Families
Arrestin family
Database Links

HGNC: 28633

KEGG: hsa:92714

STRING: 9606.ENSP00000360475

UniGene: Hs.12999

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