Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ASPSCR1 Polyclonal antibody

Uniprot No.

Q9BZE9

Target Names

ASPSCR1

Alternative Names

Alveolar soft part sarcoma chromosomal region candidate gene 1 protein antibody; Alveolar soft part sarcoma chromosome region candidate 1 (human) antibody; Alveolar soft part sarcoma locus antibody; ASPC antibody; ASPC1_HUMAN antibody; ASPCR 1 antibody; ASPCR1 antibody; ASPL antibody; ASPS antibody; ASPSCR 1 antibody; Aspscr1 antibody; FLJ45380 antibody; RCC 17 antibody; RCC17 antibody; renal cell carcinoma gene on chromosome 17 antibody; renal cell carcinoma papillary 17 antibody; Renal papillary cell carcinoma protein 17 antibody; Tether containing a UBX domain for GLUT4 antibody; Tether containing UBX domain for GLUT4 antibody; TUG antibody; UBX domain containing protein 9 antibody; UBX domain protein 9 antibody; UBX domain-containing protein 9 antibody; UBXD 9 antibody; UBXD9 antibody; UBXN 9 antibody; UBXN9 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Peptide sequence around aa.303 ~307(P-Q-Q-E-Q) derived from Human ASPSCR1.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Enhances VCP methylation catalyzed by VCPKMT.

Gene References into Functions

ASPL efficiently promotes p97 hexamer disassembly, resulting in the formation of stable p97:ASPL. Overproduction of ASPL disrupts p97 hexamer function in endoplasmic reticulum-associated protein degradation. PMID: 27762274
These results show that ASPL-TFE3 regulates cell cycle progression and induces cellular senescence by up-regulating p21 expression. PMID: 27673450
Studies indicate that alveolar soft part sarcoma showed a specific chromosomal alteration, der(17)t(X:17)(p11:q25), resulting in the fusion of the TFE3 transcription factor gene (Xp11) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25. PMID: 26516944
A conditional expression in mice of the fusion gene ASPSCR1-TFE3 from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile. PMID: 25453902
ASPL is a cofactor of the hexameric ATPase complex, known as p97. The central area in ASPL, containing both a SHP box and a UBX domain, is required for binding to the p97 N-domain. PMID: 25078495
Results support a gain-of-function role for ASPSCR1-TFE3 contributing to proliferation and survival of cancer cells. PMID: 23288701
Promotes methylation of VCP by METTL21D PMID: 23349634
Data support a model in which TUG controls p97 oligomeric status at a particular location in the early secretory pathway and in which this process regulates membrane trafficking in various cell types. PMID: 22207755
In alveolar soft part sarcomas with unusual locations or histology, we consider that the detection of the ASPSCR1-TFE3 fusion transcript would be the highly effective diagnostic technique. PMID: 21835426
Immuno-detection of TFE3 and RT-PCR-based identification of ASPL/TFE3 fusion transcripts are powerful tools in the diagnosis of alveolar soft part sarcoma. PMID: 21279521
Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of alveolar soft part sarcoma PMID: 18176180

Hide All

Involvement in disease

A chromosomal aberration involving ASPSCR1 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with TFE3 forms a ASPSCR1-TFE3 fusion protein.

Subcellular Location

Endomembrane system; Peripheral membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein. Cytoplasm. Nucleus.

Tissue Specificity

Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas.

Database Links

HGNC: 13825

OMIM: 606236

KEGG: hsa:79058

STRING: 9606.ENSP00000302176

UniGene: Hs.298351

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：
If CAPTCHA verification fails, click to refresh the CAPTCHA and try again.

Code	CSB-PA180850
Size	US$297
	Order now
Image	Western blot analysis of extracts from HL60 cells using ASPSCR1 Antibody.
Have Questions?	Leave a Message or Start an on-line Chat

ASPSCR1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background