ASPSCR1 Antibody

Datasheet

Code	CSB-PA866328ESR1HU
Size	US$166
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Image	Western blot All lanes: ASPSCR1 antibody at 8.71μg/ml + 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 61, 70, 55, 38 kDa Observed band size: 61 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA866328ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA866328ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ASPSCR1 Polyclonal antibody

Uniprot No.

Q9BZE9

Target Names

ASPSCR1

Alternative Names

Alveolar soft part sarcoma chromosomal region candidate gene 1 protein antibody; Alveolar soft part sarcoma chromosome region candidate 1 (human) antibody; Alveolar soft part sarcoma locus antibody; ASPC antibody; ASPC1_HUMAN antibody; ASPCR 1 antibody; ASPCR1 antibody; ASPL antibody; ASPS antibody; ASPSCR 1 antibody; Aspscr1 antibody; FLJ45380 antibody; RCC 17 antibody; RCC17 antibody; renal cell carcinoma gene on chromosome 17 antibody; renal cell carcinoma papillary 17 antibody; Renal papillary cell carcinoma protein 17 antibody; Tether containing a UBX domain for GLUT4 antibody; Tether containing UBX domain for GLUT4 antibody; TUG antibody; UBX domain containing protein 9 antibody; UBX domain protein 9 antibody; UBX domain-containing protein 9 antibody; UBXD 9 antibody; UBXD9 antibody; UBXN 9 antibody; UBXN9 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Tether containing UBX domain for GLUT4 protein (284-553AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Enhances VCP methylation catalyzed by VCPKMT.

Gene References into Functions

ASPL efficiently promotes p97 hexamer disassembly, resulting in the formation of stable p97:ASPL. Overproduction of ASPL disrupts p97 hexamer function in endoplasmic reticulum-associated protein degradation. PMID: 27762274
These results show that ASPL-TFE3 regulates cell cycle progression and induces cellular senescence by up-regulating p21 expression. PMID: 27673450
Studies indicate that alveolar soft part sarcoma showed a specific chromosomal alteration, der(17)t(X:17)(p11:q25), resulting in the fusion of the TFE3 transcription factor gene (Xp11) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25. PMID: 26516944
A conditional expression in mice of the fusion gene ASPSCR1-TFE3 from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile. PMID: 25453902
ASPL is a cofactor of the hexameric ATPase complex, known as p97. The central area in ASPL, containing both a SHP box and a UBX domain, is required for binding to the p97 N-domain. PMID: 25078495
Results support a gain-of-function role for ASPSCR1-TFE3 contributing to proliferation and survival of cancer cells. PMID: 23288701
Promotes methylation of VCP by METTL21D PMID: 23349634
Data support a model in which TUG controls p97 oligomeric status at a particular location in the early secretory pathway and in which this process regulates membrane trafficking in various cell types. PMID: 22207755
In alveolar soft part sarcomas with unusual locations or histology, we consider that the detection of the ASPSCR1-TFE3 fusion transcript would be the highly effective diagnostic technique. PMID: 21835426
Immuno-detection of TFE3 and RT-PCR-based identification of ASPL/TFE3 fusion transcripts are powerful tools in the diagnosis of alveolar soft part sarcoma. PMID: 21279521
Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of alveolar soft part sarcoma PMID: 18176180

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Involvement in disease

A chromosomal aberration involving ASPSCR1 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with TFE3 forms a ASPSCR1-TFE3 fusion protein.

Subcellular Location

Endomembrane system; Peripheral membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein. Cytoplasm. Nucleus.

Tissue Specificity

Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas.

Database Links

HGNC: 13825

OMIM: 606236

KEGG: hsa:79058

STRING: 9606.ENSP00000302176

UniGene: Hs.298351

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Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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