ASTL Antibody, Biotin conjugated

Code CSB-PA760708LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ASTL Polyclonal antibody
Uniprot No.
Target Names
ASTL
Alternative Names
ASTLAstacin-like metalloendopeptidase antibody; EC 3.4.-.- antibody; Oocyte astacin antibody; Ovastacin antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Astacin-like metalloendopeptidase protein (38-337AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.
Gene References into Functions
  1. The SAS1B metalloproteinase is proposed as a prototype cancer-oocyte tumor surface neoantigen for development of targeted immunotherapeutics with limited on-target/off tumor effects predicted to be restricted to the population of growing oocytes. PMID: 26327203
  2. SAS1B protein [ovastacin] shows temporal and spatial restriction to oocytes in several eutherian orders and initiates translation at the primary to secondary follicle transition. PMID: 24038607
  3. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
  4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
  5. cloning and characterization; could play in mammals a physiological function similar to that performed by hatching proteases in evolutionary distant species from arthropods to fish PMID: 15087446

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Subcellular Location
Cytoplasm. Cell membrane. Cytoplasmic vesicle, secretory vesicle, Cortical granule.
Protein Families
Peptidase M12A family
Tissue Specificity
Expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, and also in some ovarian carcinomas. Not detected in normal tissues.
Database Links

HGNC: 31704

OMIM: 608860

KEGG: hsa:431705

STRING: 9606.ENSP00000343674

UniGene: Hs.447993

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