ASTN2 Antibody

Datasheet

Code	CSB-PA002252LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: PC-3 whole cell lysate All lanes: ASTN2 antibody at 3.4µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 149, 143, 148, 50, 45 kDa Observed band size: 149 kDa Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA002252LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA002252LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA002252LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ASTN2 Polyclonal antibody

Uniprot No.

O75129

Target Names

ASTN2

Alternative Names

Astn2 antibody; ASTN2_HUMAN antibody; Astrotactin 2 antibody; Astrotactin-2 antibody; bA264C15.1 antibody; bA67K19.1 antibody; KIAA0634 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Astrotactin-2 protein (108-272AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ASTN2 Antibody (Product code: CSB-PA002252LA01HU) is Non-conjugated. For ASTN2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA002252LB01HU	ASTN2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA002252LC01HU	ASTN2 Antibody, FITC conjugated
Biotin	CSB-PA002252LD01HU	ASTN2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1. Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6).

Gene References into Functions

ASTN2 localizes primarily to endocytic and autophagocytic vesicles in the cell soma and in subsets of dendritic spines PMID: 30242134
Our study suggests that the MEF2D, PRDM16 and ASTN2 genes from GWAS are associated with migraine susceptibility, especially migraine without aura , among Chinese patients. It appears that there is no association with serotonin receptor related genes. PMID: 28058730
The findings of this study do not support a major role of ASTN2 variants in ADHD or its comorbid disorders respective aADHD associated personality traits. PMID: 27138430
Results present the structure of ASTN-2 consisting of a combination of polypeptide folds: a perforin-like domain, a minimal epidermal growth factor-like module, a unique form of fibronectin type III domain and an annexin-like domain. Structural and biophysical data show that ASTN-2 binds inositol triphosphates, suggesting a mechanism for membrane recognition or secondary messenger regulation of its activity. PMID: 27249642
The expression of coding and non-coding genes with SAFB1 cross-link sites was altered by SAFB1 knockdown. The isoform-specific expression of neural cell adhesion molecule (NCAM1) and ASTN2 was influenced by SAFB1. PMID: 26694817
Study found a significant association of ASTN2 genetic variants with age at onset in Alzheimer's disease in two independent samples together with in silico analysis that demonstrated potential role of ASTN2 in the pathogenesis of the disease PMID: 25410587
rs4836732 may contribute to hip OA susceptibility by altering proximal femur shape. PMID: 25939412
3' terminal ASTN2 deletions are significantly enriched in males with neurodevelopmental disorders, but not in females. PMID: 24381304
Single nucleotide polymorphism in ASTN2 gene is associated with cognition disorders. PMID: 22504421
Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195266

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Subcellular Location

Membrane; Multi-pass membrane protein. Perikaryon. Cytoplasm, cell cortex. Early endosome. Late endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasmic vesicle.

Protein Families

Astrotactin family

Database Links

HGNC: 17021

OMIM: 612856

KEGG: hsa:23245

STRING: 9606.ENSP00000354504

UniGene: Hs.601562

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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