ASTN2 Antibody, HRP conjugated

1. ASTN2 localizes primarily to endocytic and autophagocytic vesicles in the cell soma and in subsets of dendritic spines PMID: 30242134
2. Our study suggests that the MEF2D, PRDM16 and ASTN2 genes from GWAS are associated with migraine susceptibility, especially migraine without aura , among Chinese patients. It appears that there is no association with serotonin receptor related genes. PMID: 28058730
3. The findings of this study do not support a major role of ASTN2 variants in ADHD or its comorbid disorders respective aADHD associated personality traits. PMID: 27138430
4. Results present the structure of ASTN-2 consisting of a combination of polypeptide folds: a perforin-like domain, a minimal epidermal growth factor-like module, a unique form of fibronectin type III domain and an annexin-like domain. Structural and biophysical data show that ASTN-2 binds inositol triphosphates, suggesting a mechanism for membrane recognition or secondary messenger regulation of its activity. PMID: 27249642
5. The expression of coding and non-coding genes with SAFB1 cross-link sites was altered by SAFB1 knockdown. The isoform-specific expression of neural cell adhesion molecule (NCAM1) and ASTN2 was influenced by SAFB1. PMID: 26694817
6. Study found a significant association of ASTN2 genetic variants with age at onset in Alzheimer's disease in two independent samples together with in silico analysis that demonstrated potential role of ASTN2 in the pathogenesis of the disease PMID: 25410587
7. rs4836732 may contribute to hip OA susceptibility by altering proximal femur shape. PMID: 25939412
8. 3' terminal ASTN2 deletions are significantly enriched in males with neurodevelopmental disorders, but not in females. PMID: 24381304
9. Single nucleotide polymorphism in ASTN2 gene is associated with cognition disorders. PMID: 22504421
10. Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195266

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HGNC: 17021

OMIM: 612856

KEGG: hsa:23245

STRING: 9606.ENSP00000354504

UniGene: Hs.601562