ATP6V0D1 Antibody

Code CSB-PA004630
Size US$100
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  • Western Blot analysis of NIH-3T3 K562 cells using V-ATPase D1 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
ATP6V0D1
Alternative Names
32 kDa accessory protein antibody; ATP6D antibody; ATP6DV antibody; ATP6V0D1 antibody; ATPase H+ transporting lysosomal (vacuolar proton pump) member D antibody; ATPase H+ transporting lysosomal 38kD V0 subunit d antibody; ATPase H+ transporting lysosomal 38kDa V0 subunit d1 antibody; ATPase H+ transporting lysosomal V0 subunit d1 antibody; H(+) transporting two sector ATPase subunit D antibody; p39 antibody; V ATPase 40 KDa accessory protein antibody; V ATPase AC39 subunit antibody; V ATPase subunit d 1 antibody; V ATPase subunit D antibody; V-ATPase 40 kDa accessory protein antibody; V-ATPase AC39 subunit antibody; V-ATPase subunit d 1 antibody; V-type proton ATPase subunit d 1 antibody; VA0D1_HUMAN antibody; Vacuolar ATP synthase subunit d 1 antibody; Vacuolar proton pump subunit d 1 antibody; VATX antibody; VMA 6 antibody; VMA6 antibody; VPATPD antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human V-ATPase D1.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.
Gene References into Functions
  1. The secondary structures of d1 and d2 subunits were highly similar, but the relative stability against thermal stress was higher for d1 than d2. PMID: 24631925
  2. two adjacent enhancers inside the first intron of the neighboring (1.4 kb downstream) ATPase gene (ATP6V0D1) modulate the human AgRP promoter with profound spatiotemporal variation PMID: 19285986
  3. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia PMID: 19165527
Subcellular Location
Membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane.
Protein Families
V-ATPase V0D/AC39 subunit family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 13724

OMIM: 607028

KEGG: hsa:9114

STRING: 9606.ENSP00000290949

UniGene: Hs.106876

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