ATP6V1B2 Antibody

Datasheet

Code	CSB-PA002398ESR1HU
Size	US$166
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Image	Western blot All lanes: ATP6V1B2 antibody at 5µg/ml + Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 57 kDa Observed band size: 57 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ATP6V1B2 Polyclonal antibody

Uniprot No.

P21281

Target Names

ATP6V1B2

Alternative Names

ATP6B1B2 antibody; ATP6B2 antibody; ATP6V1 B2 antibody; ATP6V1B 2 antibody; ATP6V1B2 antibody; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B isoform 2 antibody; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B2 antibody; ATPase H+ transporting, lysosomal (vacuolar proton pump) beta polypeptide 56/58kD isoform 2 antibody; ATPase, H+ transporting, lysosomal V1 subunit B2 antibody; brain isoform antibody; Endomembrane proton pump 58 kDa subunit antibody; H+ transporting two sector ATPase antibody; HO 57 antibody; HO57 antibody; V ATPase B2 subunit antibody; V ATPase subunit B 2 antibody; V type proton ATPase subunit B, brain isoform antibody; V-ATPase subunit B 2 antibody; V-type proton ATPase subunit B antibody; Vacuolar ATP synthase subunit B brain isoform antibody; Vacuolar H+ ATPase 56,000 subunit antibody; Vacuolar H+ ATPase 56000 subunit antibody; Vacuolar H+ATPase B2 antibody; Vacuolar proton pump subunit B 2 antibody; VAT B2 antibody; VATB 2 antibody; VATB antibody; VATB2 antibody; VATB2_HUMAN antibody; Vma 2 antibody; Vma2 antibody; VPP 3 antibody; VPP3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human V-type proton ATPase subunit B, brain isoform protein (262-511AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load.

Gene References into Functions

We conclude that the effects of variation in the vacuolar ATPase may point to a new molecular mechanism that influences the long-term development of depression. This mechanism may involve dysfunction specifically in hippocampal circuitry and cognitive impairment that characterizes recurrent and chronic depression. PMID: 27824360
ATP6V1B2 is somatically mutated in 22% of follicular lymphoma tumors. Mutation hotspots found at Y371 and R400. PMID: 25713363
A missense mutation in ATP6V1B2 associated with Zimmermann-Laband syndrome. PMID: 25915598
The ATP6V1B2 p.Arg506X is a haploinsufficient mutation and resulted in abnormal acidification in lysosomes. PMID: 24913193
This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia PMID: 20381070

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Involvement in disease

Zimmermann-Laband syndrome 2 (ZLS2); Deafness, congenital, with onychodystrophy, autosomal dominant (DDOD)

Subcellular Location

Apical cell membrane. Melanosome. Cytoplasm.

Protein Families

ATPase alpha/beta chains family

Tissue Specificity

Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level).

Database Links

HGNC: 854

OMIM: 124480

KEGG: hsa:526

STRING: 9606.ENSP00000276390

UniGene: Hs.295917

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Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

mTOR signaling pathway Oxidative Phosphorylation Synaptic vesicle cycle

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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