Acetyl-Histone H2B (K126) Antibody

Datasheet

Code	CSB-PA000114
Size	US$119
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Image	Western Blot analysis of A549 cells using Acetyl-Histone H2B (K126) Polyclonal Antibody Western Blot analysis of A549 cells using Acetyl-Histone H2B (K126) Polyclonal Antibody
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q96A08

Target Names

HIST1H2BA

Alternative Names

HIST1H2BA antibody; testis antibody; bA317E16.3 antibody; H2B antibody; H2B histone family member U antibody; H2B histone family member U testis specific antibody; H2B histone family; member U; (testis specific) antibody; H2B testis antibody; H2B1A_HUMAN antibody; H2BFU antibody; H2BT antibody; HIST1H2BA antibody; Histone 1; H2ba antibody; Histone cluster 1 H2ba antibody; Histone H2B antibody; Histone H2B testis antibody; Histone H2B type 1 A antibody; Histone H2B type 1-A antibody; Histone H2B type 1A antibody; STBP antibody; Testis specific histone H2B antibody; Testis-specific histone H2B antibody; TSH 2B antibody; TSH2B antibody; TSH2B.1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Human Histone H2B around the acetylation site of K126.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear.

Gene References into Functions

In a process of single-strand DNA repair, PARP3 mono-ADP-ribosylates nucleosomal histone H2B. PMID: 27716488
Data indicate that lactate dehydrogenase A (LDHA) is involved in the transcription of histone 2B gene. PMID: 28257841
Data show that histone H2B of prostate cancer cell line DU-145 have hypoacetylation, hypomethylation, and dephosphorylation, suggesting there was an excessive histone deacetylase activity in the cells. PMID: 26759222
Reconstituted TSH2B containing octamers are able to form nucleosome core particles which are structurally and dynamically indistinguishable from those reconstituted with octamers consisting of only native histones. PMID: 15709765

Subcellular Location

Nucleus. Chromosome.

Protein Families

Histone H2B family

Tissue Specificity

Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells.

Database Links

HGNC: 18730

OMIM: 609904

KEGG: hsa:255626

STRING: 9606.ENSP00000274764

UniGene: Hs.591786

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

What Are Histones: Unraveling Their Critical Roles in Disease Pathogenesis Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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