Alb Antibody

Code CSB-PA00010E1Rb
Size US$299
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Product Details

Full Product Name Rabbit anti-Rattus norvegicus (Rat) Alb Polyclonal antibody
Uniprot No. P02770
Target Names Alb
Alternative Names Alb 1 antibody; alb antibody; ALBU_RAT antibody; Albumin antibody; Serum albumin antibody
Raised in Rabbit
Species Reactivity Rat
Immunogen Serum Albumin purified from Rat serum (Native Protein)
Immunogen Species Rattus norvegicus (Rat)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene References into Functions
  1. Tubular Expression and Urinary Excretion of MMP-9 Protein Were Increased in Association with Albumin Overload in the Diabetic Kidneys. PMID: 28805677
  2. albumin immunoreactivity was newly observed in microglia in the hippocampal CA1 region following 5 min of transient cerebral ischemia. These results indicate that transient ischemia-induced albumin expression in microglia might be associated with ischemia-induced 'delayed neuronal death' in the hippocampal CA1 pyramidal neurons. PMID: 28586018
  3. significant structural changes occur to albumin with glycation, particularly in the FcRn-binding region, which could explain the reduced affinity to FcRn PMID: 26887834
  4. Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3 PMID: 26806786
  5. Megalin/cubilin and lysosome rupture is involved in albumin-triggered tubular injury and tubulointerstitial inflammation. PMID: 26025362
  6. Both insulin and high glucose concentrations enhance the permeability of podocytes to albumin by stimulating oxygen free radical production, primarily by NAD(P)H oxidase-4 (NOX4), and by activating protein kinase G, isoform Ialpha. PMID: 25888796
  7. Overall, rats with albumin deficiency display enhanced glucose tolerance, insulin secretion and gluconeogenic flux. PMID: 22198013
  8. albumin prevents 6-hydroxydopamine-induced loss of tyrosine hydroxylase PMID: 22815976
  9. Data indicate that transcription of Alb is regulated by a complicated system of distant enhancers. PMID: 21858039
  10. This pioneering study determined a higher level of ischemia-modified albumin in a testicular torsion model. PMID: 20452583
  11. Forced expression of PPAR-gamma or C/EBP-alpha in activated pancreatic stellate cells induced albumin expression, thereby reverting cells to the quiescent phenotype. PMID: 19932685
  12. Catalysis of S-nitrosothiols formation by serum albumin: the mechanism and implication in vascular control PMID: 11983891
  13. This study suggests that Aroclor 1254 induces elevated albumin serum levels indirectly through induction of liver-enriched transcription factors, which regulate albumin gene expression PMID: 12051991
  14. an accelerated plasma efflux of albumin contributes to hypoalbuminemia only during the early period of sepsis PMID: 12571074
  15. albumin affects glucose metabolism by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism PMID: 12970360
  16. Kinetics of albumin production during rat liver development. PMID: 17879097

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Subcellular Location Secreted
Protein Families ALB/AFP/VDB family
Tissue Specificity Plasma.
Database Links

KEGG: rno:24186

STRING: 10116.ENSRNOP00000003921

UniGene: Rn.202968

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