B2M Antibody

Datasheet
Code CSB-PA002486YA01HU
See More Details Free Antibody trial simple
Size US$299Purchase it in Cusabio online store
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Uniprot No. P61769
Image
  • Western blot
    All lanes: B2M antibody at 2µg/ml
    Lane 1: A431 whole cell lysate
    Lane 2: Mouse lung tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 14 kDa
    Observed band size: 14 kDa

  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA002486YA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA002486YA01HU at dilution of 1:100

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human Beta-2-microglobulin protein (21-119AA)
Raised in Rabbit
Species Reactivity Human, Mouse
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200
Relevance Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3], B2M
Immunogen Species Human
Research Area Cardiovascular
Protocol
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Target Names B2M
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation
Involvement in disease Immunodeficiency 43 (IMD43); Amyloidosis 8 (AMYL8)
Subcellular Location Secreted, Cell surface, Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280), SUBCELLULAR LOCATION:
Protein Families Beta-2-microglobulin family
Database Links

HGNC: 914

OMIM: 105200

KEGG: hsa:567

STRING: 9606.ENSP00000452780

UniGene: Hs.534255

Pathway Antigen processing and presentation

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