B4GALT5 Antibody

Code CSB-PA004624
Size US$119
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  • Western Blot analysis of 293 cells using β-1,4-Gal-T5 Polyclonal Antibody
  • Western Blot analysis of K562 cells using β-1,4-Gal-T5 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
B4GALT5
Alternative Names
4-galactosyltransferase 5 antibody; 4-GalT II antibody; 4-GalTase 5 antibody; B4Gal T5 antibody; b4Gal-T5 antibody; B4galt5 antibody; B4GT5_HUMAN antibody; Beta 1 4 galactosyltransferase 5 antibody; Beta 1 4 galactosyltransferase V antibody; Beta 1 4 GalT II antibody; Beta 1 4 GalT IV antibody; Beta 1 4 GalTase 5 antibody; Beta-1 antibody; Beta-1,4-galactosyltransferase 5 antibody; Beta-1,4-GalT II antibody; Beta-1,4-GalTase 5 antibody; Beta4 GALT IV antibody; Beta4Gal T5 antibody; Beta4Gal-T5 antibody; Beta4GalT V antibody; gt V antibody; gtV antibody; MGC138470 antibody; UDP Gal:beta GlcNAc beta 1 4 galactosyltransferase 5 antibody; UDP Gal:betaGlcNAc beta 1 4 galactosyltransferase 5 antibody; UDP Gal:betaGlcNAc beta 1 4 galactosyltransferase polypeptide 5 antibody; UDP galactose:beta N acetylglucosamine beta 1 4 galactosyltransferase 5 antibody; UDP-Gal:beta-GlcNAc beta-1 antibody; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5 antibody; UDP-galactose:beta-N-acetylglucosamine beta-1 antibody; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of Human β-1,4-Gal-T5.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation. Plays a role in the glycosylation of BMPR1A and regulation of its protein stability. Essential for extraembryonic development during early embryogenesis.
Gene References into Functions
  1. 2.3-kb 5'-flanking region of the human beta-1,4-GalT V gene was cloned and the region -116/-18 relative to the transcription start site as that having promoter activity. PMID: 15263012
  2. B4GALT1 and B4GALT5, two members of B4GALT gene family, are involved in the development of multidrug resistance of human leukemia cells. PMID: 23744354
  3. The expression of the beta-1,4-GalT V gene has been shown to be regulated by transcription factors Sp1 and Ets-1 in cancer cells.(review) PMID: 22687727
  4. These data reveal a critical role of beta1,4GalT V in the self-renewal and tumorigenicity of glioma-initiating cells. PMID: 20417617
  5. Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line PMID: 12385586
  6. results suggest that GalT V functioned as a novel glioma growth activator and might represent a novel target in glioma therapy PMID: 16461357
  7. Ets-1 enhances expression of the beta-1,4-GalT V gene through activation of the Sp1 gene in cancer cells PMID: 17656364

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Subcellular Location
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Golgi apparatus.
Protein Families
Glycosyltransferase 7 family
Tissue Specificity
Ubiquitously expressed.
Database Links

HGNC: 928

OMIM: 604016

KEGG: hsa:9334

STRING: 9606.ENSP00000360776

UniGene: Hs.370487

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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