BCL2L13 Antibody

Code CSB-PA002617GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
BCL2L13
Alternative Names
BCL2L13; MIL1; CD003; Bcl-2-like protein 13; Bcl2-L-13; Bcl-rambo; Protein Mil1
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human BCL2L13
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May promote the activation of caspase-3 and apoptosis.
Gene References into Functions
  1. Ectopically expressed in Drosophila Bcl-rambo localizes to mitochondria, induces apoptosis and atrophied wing, split thorax, and rough eye phenotypes. PMID: 27348811
  2. This study showed that Bcl-2-like protein 13 (Bcl2-L-13) induces mitochondrial fragmentation and mitophagy in mammalian cells. PMID: 26146385
  3. Bcl2L13 binds to proapoptotic ceramide synthases 2 (CerS2) and 6 (CerS6) via a unique C-terminal 250-aa sequence located between its Bcl-2 homology and membrane anchor domains and blocks homo- and heteromeric CerS2/6 complex formation and activity. PMID: 24706805
  4. Bcl-rambo is a pro-apoptotic member of the Bcl-2 family, inducing the permeability transition via interaction with the adenine nucleotide translocator (ANT). PMID: 22921587
  5. Our data support the speculation that the Alu element insertion during the splicing process may play an important role in the generation of protein diversity in primate cells by a yet uncharacterized mechanism PMID: 12527362
  6. SidF contributes to apoptosis resistance in L. pneumophila-infected cells by specifically interacting with and neutralizing the effects of BNIP3 and Bcl-rambo, two proapoptotic members of Bcl2 protein family. PMID: 17360363

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Subcellular Location
[Isoform 2]: Mitochondrion membrane; Single-pass membrane protein. Nucleus.; [Isoform 1]: Nucleus.
Protein Families
Bcl-2 family
Tissue Specificity
Ubiquitous, with the highest levels of expression in heart, placenta and pancreas.
Database Links

HGNC: 17164

KEGG: hsa:23786

STRING: 9606.ENSP00000318883

UniGene: Hs.631672

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