BHLHA15 Antibody

Datasheet

Code	CSB-PA755911LA01HU
Size	US$166
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Image	IHC image of CSB-PA755911LA01HU diluted at 1:150 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) BHLHA15 Polyclonal antibody

Uniprot No.

Q7RTS1

Target Names

BHLHA15

Alternative Names

Basic helix loop helix domain containing class B 8 antibody; Basic helix loop helix family member a15 antibody; BHA15_HUMAN antibody; Bhlha15 antibody; bHLHB8 antibody; Class A basic helix-loop-helix protein 15 antibody; Class B basic helix-loop-helix protein 8 antibody; Class II bHLH protein MIST1 antibody; intestine and stomach expression 1 antibody; MIST 1 antibody; MIST-1 antibody; MIST1 antibody; Muscle antibody; Muscle intestine and stomach expression 1 antibody; protein MIST1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Class A basic helix-loop-helix protein 15 protein (2-72AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The BHLHA15 Antibody (Product code: CSB-PA755911LA01HU) is Non-conjugated. For BHLHA15 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA755911LB01HU	BHLHA15 Antibody, HRP conjugated	ELISA
FITC	CSB-PA755911LC01HU	BHLHA15 Antibody, FITC conjugated
Biotin	CSB-PA755911LD01HU	BHLHA15 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3'.

Gene References into Functions

noted a higher mean value of microvascular density in CK5/6 and Ep-CAM-immunopositive tumors, carcinomas with aberrant CK8/18 expression, and carcinomas with no or strong expression of MMP-2 in stromal fibroblast-like cells PMID: 22495370
Activation of protein kinase Cdelta leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1. PMID: 22374815
Chief cells emerge from the Mist. PMID: 21907708
MIST1 is enriched upon plasma cell differentiation. PMID: 21098683
Our findings implicate MIST1 as a reliable marker of mature, healthy chief cells, and we provide the first evidence that metaplasia in humans arises at least in part from the chief cell lineage. PMID: 20709804
MIST1 binds to highly conserved CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D. PMID: 20038531
Mist1 within the hierarchy of known helix-loop-helix/basic helix-loop-helix proteins that control mammary epithelial cell development PMID: 16645041

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Subcellular Location

Nucleus.

Tissue Specificity

Expressed in brain, liver, spleen and skeletal muscle.

Database Links

HGNC: 22265

OMIM: 608606

KEGG: hsa:168620

STRING: 9606.ENSP00000326391

UniGene: Hs.511979

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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