BRINP3 Antibody

Datasheet
Code CSB-PA755233LA01HU
See More Details
Size US$299
Uniprot No. Q76B58
Image
  • Western Blot
    Positive WB detected in: K562 whole cell lysate, Colo320 whole cell lysate, SH-SY5Y whole cell lysate, A549 whole cell lysate, PC-3 whole cell lysate
    All lanes: BRINP3 antibody at 3.8µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 89, 77 kDa
    Observed band size: 77 kDa

  • IHC image of CSB-PA755233LA01HU diluted at 1:600 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunogen Recombinant Human BMP/retinoic acid-inducible neural-specific protein 3 protein (389-487AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000
Relevance Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias BMP/retinoic acid-inducible neural-specific protein 3 (DBCCR1-like protein 1), BRINP3, DBCCR1L DBCCR1L1 FAM5C
Immunogen Species Human
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Research Area Cell Biology
Target Names BRINP3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.
Subcellular Location Secreted, Mitochondrion
Protein Families BRINP family
Tissue Specificity Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.
Database Links

HGNC: 22393

KEGG: hsa:339479

STRING: 9606.ENSP00000356432

UniGene: Hs.65765

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