C1QC Antibody, FITC conjugated

Code CSB-PA003641LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) C1QC Polyclonal antibody
Uniprot No.
Target Names
C1QC
Alternative Names
AI385742 antibody; C1Q C antibody; C1qc antibody; C1QC_HUMAN antibody; C1QG antibody; Complement C1q subcomponent subunit C antibody; Complement component 1; q subcomponent; C chain antibody; complement component 1; q subcomponent; gamma polypeptide antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Complement C1q subcomponent subunit C protein (27-157AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Gene References into Functions
  1. Neuromyelitis optica patients had higher levels of C3a and anti-C1q antibodies than healthy controls. PMID: 25109258
  2. C1q deficiency due to a Gly164Ser mutation may have a role in Rothmund-Thomson syndrome and glomerulonephritis [case report] PMID: 24157463
  3. C1q and C1q receptor interaction may be responsible for the C1q-mediated migration of mesenchymal stromal cells. PMID: 22264191
  4. Three single nucleotide polymorphisms (STAT6 rs703817, C1qG rs17433222, and MBP rs3794845) were found to be significantly associated with childhood leukemia risk in Koreans. PMID: 20438785
  5. These results suggest a novel pathway in which C1q and MBL influence removal and metabolism of atherogenic forms of LDL in the early stages of atherosclerosis. PMID: 20833838
  6. prevents monocyte-derived dendritic cell differentiation PMID: 19710097
  7. The C-terminal globular region of the C1Q C chain may have evolved as a functionally specialized domain or module with distinct binding properties which together with the A and B chains confers versatility and flexibility to the whole C1q molecule. PMID: 12847249
  8. Complementary interacting sites on the C1q globular domain have been precisely defined. Characterization of point mutants suggests a complementary role for Arg156 of C1Q C chain in the C1q-IgG interaction. PMID: 15034050
  9. C1q polymorphisms are associated with SLE, serum C1q and CH50 levels in a stable founder population of patients with SLE. PMID: 18504288
  10. The peripheral globular region of the C1q molecule displays a lectin-like activity, which contributes to DNA binding through interaction with its deoxy-d-ribose moiety and may participate in apoptotic cell recognition. PMID: 18703056
  11. Complement C1q chemoattracts human dendritic cells and enhances migration of mature dendritic cells to CCL19 via activation of AKT and MAPK pathways.( PMID: 18838169
  12. Complement protein C1q and anti-hexon antibodies together can mediate efficient adenovirus infection in coxsackie and adenovirus receptor-negative cell types. PMID: 19115936
  13. C1QC (rs9434) correlates with later age of onset in TTR Val30Met familial amyloidotic polyneuropathy. C1QC (rs15940) does not. PMID: 19493541
  14. C1q deficiency is such a strong risk factor for systemic lupus erythematosus. PMID: 19790049

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Involvement in disease
Complement component C1q deficiency (C1QD)
Subcellular Location
Secreted.
Database Links

HGNC: 1245

OMIM: 120575

KEGG: hsa:714

STRING: 9606.ENSP00000363768

UniGene: Hs.467753

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