C6 Antibody

Code CSB-PA001093
Size US$100
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  • Western Blot analysis of HuvEc cells using C6 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
C6
Alternative Names
AW111623 antibody; C6 antibody; CO6_HUMAN antibody; Complement component 6 antibody; Complement component C6 antibody
Raised in
Rabbit
Species Reactivity
Human,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human C6.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Gene References into Functions
  1. Our study provided novel evidence that genetic variations in complement genes C6 and MASP1were associated with preeclampsia risk, and that the risk varied by preeclampsia subtypes PMID: 27405496
  2. recipient C6 rs9200 polymorphism is associated with HCC recurrence after OLT, and improves the predictive value of clinical models. PMID: 27173880
  3. Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC). PMID: 22267737
  4. finding of very high serious morbidity in patients with complete C6 deficiency due to meningococcal infections PMID: 22288589
  5. Genetic polymorphisms in C6 gene do not influence the risk of aspirin hypersensitivity in Korean asthmatic patients. PMID: 21704099
  6. produced by trophoblast cells PMID: 19665237
  7. The most common defect, which leads to an increased susceptibility to Neisseria meningitidis infections in the Western Cape, is 879delG. PMID: 17257682

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Involvement in disease
Complement component 6 deficiency (C6D)
Subcellular Location
Secreted.
Protein Families
Complement C6/C7/C8/C9 family
Database Links

HGNC: 1339

OMIM: 217050

KEGG: hsa:729

STRING: 9606.ENSP00000263413

UniGene: Hs.481992

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