C7 Antibody

Code CSB-PA004145GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
C7
Alternative Names
C7 antibody; CO7_HUMAN antibody; complement component 7 antibody; Complement component C7 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human C7
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.
Gene References into Functions
  1. this study shows that GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C PMID: 29966690
  2. Two case reports of C7 deficiency leading to recurrent meningitis and other bacterial infections are described. PMID: 28078901
  3. The complement C7 rs6876739 CC genotypes and mannan-binding lectin (MBL2) gene polymorphisms of liver donors were significantly associated with bacterial infection in recipients. PMID: 27063552
  4. Complement proteins C7 and CFH control the stemness of liver cancer cells via LSF-1 pathway. PMID: 26723877
  5. Borrelial CspA binds the human terminal complement components C7 and C9 and blocks assembly and membrane insertion of the terminal complement complex (TCC). PMID: 23943762
  6. Studies indicate that the deletion defect may be a more commonly distributed cause of C7 deficiency in Ireland. PMID: 22206826
  7. C7 isoelectric focusing variants can determine meningococcal killing in the early stage of infection when antibody-independent killing prevails. PMID: 19931914
  8. To determine transcriptional regulation of the human complement component C7, a 1 kb promoter fragment was cloned and the transcription start site was determined. C7 is expressed by the hepatoma-derived cell line Hep-3B, but not by Hep-G2. PMID: 12595902
  9. The interaction between the factor I domain of C7 and the C345C domain at the C terminus of the C5 alpha-chain plays an essential role in complement membrane attack complex formation and complement lytic activity. PMID: 15879120
  10. recurrence of fulminant meningococcal disease in a complement component C7-deficient patient PMID: 15889368
  11. membrane associated C7 acts as a trap for the late complement components to control excessive inflammation induced by SC5b-9 PMID: 19179470
  12. C7 is associated with multiple sclerosis pathogenesis. PMID: 19221116
  13. Data show that the two C7-FIMs pack closely together with an approximate 2-fold rotational symmetry that is rarely seen in module pairs and has not been observed in FD-containing proteins. PMID: 19419965

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Involvement in disease
Complement component 7 deficiency (C7D)
Subcellular Location
Secreted.
Protein Families
Complement C6/C7/C8/C9 family
Database Links

HGNC: 1346

OMIM: 217070

KEGG: hsa:730

STRING: 9606.ENSP00000322061

UniGene: Hs.669878

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