CACNA2D2 Antibody

Datasheet

Code	CSB-PA080289
Size	US$100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9NY47

Target Names

CACNA2D2

Alternative Names

Alpha 2 delta calcium channel subunit antibody; CA2D2_HUMAN antibody; CACNA2D antibody; Cacna2d2 antibody; Calcium channel, voltage-dependent, alpha 2/delta subunit 2 antibody; Calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26 antibody; Calcium voltage gated channel auxiliary subunit alpha2delta 2 antibody; Gene 26 antibody; KIAA0558 antibody; LUAC11.1 antibody; Voltage-dependent calcium channel subunit alpha-2/delta-2 antibody; Voltage-dependent calcium channel subunit delta-2 antibody; Voltage-gated calcium channel subunit alpha-2/delta-2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic Peptide

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Form

Liquid

Tested Applications

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000

Protocols

Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.

Gene References into Functions

show that the action of alpha2delta2 on tumor development occurs not only through a stimulation of proliferation PMID: 25619833
The investigation of single nucleotide polymorphisms in three genes that have a functional impact on the opioid response: OPRM1, ABCB1 and the calcium channel complex subunit CACNA2D2, is reported. PMID: 23402298
CACNA2D2 deletion/methylation is associated with cervical disease progression. PMID: 21809394
single nucleotide polymorphism identified PMID: 11851383
role in apoptosis in non-small cell lung cancer cells via association with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity PMID: 12555074
In mice, targeted disruption of Cacna2d2 led to growth retardation, reduced life span, ataxia, enhanced susceptibility to seizures, and cardiac abnormalities. Cacna2d2 may be involved in hereditary cerebellar ataxias and epileptic disorders in humans. PMID: 15331424
Although transgenic du(2J)/+ mice have a marked reduction in alpha2delta-2 protein, they show no fall in Purkinje somatic calcium currents or increase in cerebellar tyrosine hydroxylase gene expression. PMID: 17135419

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Calcium channel subunit alpha-2/delta family

Tissue Specificity

Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta an

Database Links

HGNC: 1400

OMIM: 607082

KEGG: hsa:9254

STRING: 9606.ENSP00000418081

UniGene: Hs.476273

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

MAPK signaling pathway Cardiac muscle contraction

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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