CACNA2D2 Antibody

Code CSB-PA889145ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
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  • Western blot
    All lanes: CACNA2D2 antibody IgG at 4.51μg/ml + Mouse brain tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 130, 123, 131 kDa
    Observed band size: 130 kDa

  • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA889145ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA889145ESR2HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CACNA2D2 Polyclonal antibody
Uniprot No. Q9NY47
Target Names CACNA2D2
Alternative Names Alpha 2 delta calcium channel subunit antibody; CA2D2_HUMAN antibody; CACNA2D antibody; Cacna2d2 antibody; Calcium channel, voltage-dependent, alpha 2/delta subunit 2 antibody; Calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26 antibody; Calcium voltage gated channel auxiliary subunit alpha2delta 2 antibody; Gene 26 antibody; KIAA0558 antibody; LUAC11.1 antibody; Voltage-dependent calcium channel subunit alpha-2/delta-2 antibody; Voltage-dependent calcium channel subunit delta-2 antibody; Voltage-gated calcium channel subunit alpha-2/delta-2 antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-2 protein (20-200AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Global DNA methylation pattern involved in the modulation of differentiation potential of adipogenic and myogenic precursors in skeletal muscle of pigs. Zhang, X,Stem Cell Research & Therapy,2020

Applications: WB
Sample species: Human
Sample type: Cell
Review: Western bolt assays showed that the mRNA expression level of CACNA2D2 (b) protein levels of CACNA2D2 (c-f) in myogenic precursors transfected with CACNA2D2-plasmid or empty vector in growth medium at 0, 12, 24, and 48 h, respectively. Data were presented as means ± SEM (n = 3)
PMID: 33308295

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Target Data

Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
Gene References into Functions
  1. show that the action of alpha2delta2 on tumor development occurs not only through a stimulation of proliferation PMID: 25619833
  2. The investigation of single nucleotide polymorphisms in three genes that have a functional impact on the opioid response: OPRM1, ABCB1 and the calcium channel complex subunit CACNA2D2, is reported. PMID: 23402298
  3. CACNA2D2 deletion/methylation is associated with cervical disease progression. PMID: 21809394
  4. single nucleotide polymorphism identified PMID: 11851383
  5. role in apoptosis in non-small cell lung cancer cells via association with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity PMID: 12555074
  6. In mice, targeted disruption of Cacna2d2 led to growth retardation, reduced life span, ataxia, enhanced susceptibility to seizures, and cardiac abnormalities. Cacna2d2 may be involved in hereditary cerebellar ataxias and epileptic disorders in humans. PMID: 15331424
  7. Although transgenic du(2J)/+ mice have a marked reduction in alpha2delta-2 protein, they show no fall in Purkinje somatic calcium currents or increase in cerebellar tyrosine hydroxylase gene expression. PMID: 17135419

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Calcium channel subunit alpha-2/delta family
Tissue Specificity Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta an
Database Links

HGNC: 1400

OMIM: 607082

KEGG: hsa:9254

STRING: 9606.ENSP00000418081

UniGene: Hs.476273

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