CACNB2 Antibody

1. Data show that an indispensable beta-subunit of the voltage-gated Ca(2+) channel Cav1.2 interaction with H-Ras is independently of Ca(2+) flux, suggesting the regulatory role of beta2 in transcriptional activation via the ERK/CREB pathway. PMID: 30150369
2. Our study shows that palmitoylation of CaVbeta2a is necessary for CaValpha1 trafficking to the plasma membrane. However, excessive number of palmitoylated CaVbeta2a leads to Ca(2+) overload and beta cell death. PMID: 28739256
3. Study showed that CACNB2 is a possible candidate hypertrophy-modifying gene contributing to disease variability of MYBPC3-associated familial hypertrophic cardiomyopathy PMID: 28614222
4. Five serious mental disorders and three major cardiovascular diseases have recently been linked to the CACNB2 gene coding for the Cavbeta2 subunits PMID: 25966706
5. ADM genotype AA was associated with the highest values of systolic and diastolic blood pressure (BP), while CACNB2 genotype CC carriers had the highest values of diastolic BP in childhood. PMID: 25313554
6. In the gene-based analysis, CACNB2 and CTCF showed the strongest evidence for association with schizophrenia in both the present samples and in those of the Psychiatric Genetics Consortium datasets. PMID: 24901509
7. Three rare missense mutations of CACNB2 (G167S, S197F, and F240L) found in Autism Spectrum Disorders (ASD)-affected families, are reported. PMID: 24752249
8. Association of the SNP rs2932538 in MOV10 and SNP rs4373814 in CACNB2 with an increased risk of hypertension in a Chinese Han population. PMID: 24338417
9. Genetic variations in CYP17A1, CACNB2 and PLEKHA7 were related to blood pressure traits and/or hypertension in Chinese She population. PMID: 21963141
10. Genetic testing reveals disease-causing mutations in depolarizing sodium (SCN5A) or calcium (CaCNB2b) channels in 5 infants with rapid ventricular tachycardia, conduction abnormalities, and Brugada-like syndrome. PMID: 22090166
11. This study provided that cacnb2 are associated with Bipolar I in the Han Chinese population. PMID: 20386566
12. that genetic variation within CACNB2 may influence treatment-related outcomes in high-risk patients with hypertension. PMID: 21156931
13. CACNB2 is a possible novel early repolarization syndrome susceptibility gene. PMID: 20817017
14. We also identified a novel polymorphism (D601E) in CACNB2b that slowed inactivation of L-type calcium current (I(Ca,L)), significantly increased total charge. Slowed conduction was present. PMID: 20025708
15. Functional properties of the CaV1.2 calcium channel activated by calmodulin in the absence of alpha2delta subunits. PMID: 19106618
16. CACNB2 SNPs show genotypic association with Alzheimer disease. PMID: 19241460
17. The first Brugada syndrome mutation in CaCNB2b resulting in accelerated inactivation of L-type calcium channel current, is reported. PMID: 19358333

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HGNC: 1402

OMIM: 600003

KEGG: hsa:783

STRING: 9606.ENSP00000320025

UniGene: Hs.59093