CACNB4 Antibody

Datasheet

Code	CSB-PA004414LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA004414LA01HU at dilution of 1:100 Immunofluorescent analysis of PC-3 cells using CSB-PA004414LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CACNB4 Polyclonal antibody

Uniprot No.

O00305

Target Names

CACNB4

Alternative Names

CAB4 antibody; CACB4_HUMAN antibody; Cacnb4 antibody; CACNLB4 antibody; Calcium channel voltage dependent beta 4 subunit antibody; Calcium channel voltage dependent subunit beta 4 antibody; Calcium channel voltage-dependent subunit beta 4 antibody; Dihydropyridine sensitive L type calcium channel beta 4 subunit antibody; EA5 antibody; EIG9 antibody; EJM antibody; EJM4 antibody; EJM6 antibody; Voltage-dependent L-type calcium channel subunit beta-4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Voltage-dependent L-type calcium channel subunit beta-4 protein (1-217AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CACNB4 Antibody (Product code: CSB-PA004414LA01HU) is Non-conjugated. For CACNB4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA004414LB01HU	CACNB4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004414LC01HU	CACNB4 Antibody, FITC conjugated
Biotin	CSB-PA004414LD01HU	CACNB4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Gene References into Functions

The nuclear targeting properties of the truncated beta(4b(1-481)) subunit in tsA-201 cells, skeletal myotubes, and in hippocampal neurons, were investigated. PMID: 24875574
Genome-wide association studies identify CACNB4 mutation releated to juvenile myoclonic epilepsy. PMID: 23756480
Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy PMID: 22892567
The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 gama via a PXVXL binding motif. PMID: 21220418
CACNB4 is associated with acute lung injury in mice PMID: 21297076
The novel nucleotide substitution T87C (D29D)in CACNB4 was observed in 2 migrainous vertigo patients and was not present in control DNA samples. PMID: 16866717
No pathogenic mutation were identified in CACNB4. PMID: 18446307
plays a role in neurotransmitter release. PMID: 18712068

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Involvement in disease

Epilepsy, idiopathic generalized 9 (EIG9); Juvenile myoclonic epilepsy 6 (EJM6); Episodic ataxia 5 (EA5)

Protein Families

Calcium channel beta subunit family

Tissue Specificity

Expressed predominantly in the cerebellum and kidney.

Database Links

HGNC: 1404

OMIM: 601949

KEGG: hsa:785

STRING: 9606.ENSP00000438949

UniGene: Hs.120725

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

MAPK signaling pathway Cardiac muscle contraction

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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