CACNG2 Antibody

1. TARP gamma-2 reduces the ability of low glutamate concentrations to cause AMPAR desensitization and enhances channel gating at low glutamate occupancy. PMID: 28768197
2. Our nanopositioning data place stargazin below the AMPA receptor ligand-binding domain, where it is well poised to act as a scaffold to facilitate the long-range conformational selection observations seen in single-molecule experiments. These data support a model of stargazin acting to stabilize or select conformational states that favor activation. PMID: 27705782
3. In addition to changes in MEK3 gene regulation, our study demonstrated upregulation of CACNG2 and GADD45G at the mRNA level in CMM patients. PMID: 27418173
4. A transient positive feedback mechanism between AMPAR and stargazin has implications for information processing in the brain, because it should allow activity-dependent facilitation of excitatory synaptic transmission through a postsynaptic mechanism. PMID: 26744192
5. The additional cleft closure and/or stabilization of the more closed-cleft states of the LBD is expected to translate to higher agonist efficacy and could contribute to the structural mechanism for stargazin modulation of AMPAR function. PMID: 25422502
6. Autoinactivation is a subunit and splice form dependent property of AMPA receptor-stargazin complexes, which involves structural rearrangements within the complex rather than any physical dissociation. PMID: 23166629
7. Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2 PMID: 20688780
8. These results suggest that stargazin (gamma-2) not only promotes AMPA receptor surface expression but also directly modulates AMPA receptor activity. PMID: 15567474
9. AMPA receptors complexed with stargazin are significantly more responsive to synaptically released glutamate compared with AMPA receptors lacking stargazin. PMID: 15758178
10. Stargazin enhances trafficking of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors GluR1 and GluR2 by blocking endoplasmic reticulum retention. PMID: 16793768
11. the Q/R site modulates the interaction of stargazin with the transmembrane domains of AMPA receptors via an allosteric mechanism and that this modulation leads to the observed differences in the electrophysiological properties of the receptor PMID: 17483093
12. Stargazin polymorphisms may play a role in the response to lithium treatment. PMID: 18408563
13. The genes CACNG2 might be vulnerability genes for neuropsychologically defined subgroups of schizophrenic patients. PMID: 18571626
14. findings show stargazin demonstrates differential control of AMPA receptor subunit stability PMID: 19543281
15. Data show that S-nitrosylation of stargazin increases binding to the AMPAR subunit GluR1, causing increased surface expression of the AMPAR. PMID: 19805317

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HGNC: 1406

OMIM: 602911

KEGG: hsa:10369

STRING: 9606.ENSP00000300105

UniGene: Hs.146766