CACYBP Antibody, FITC conjugated

Code CSB-PA872536LC01HU
Size US$166
Order now
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CACYBP Polyclonal antibody
Uniprot No.
Target Names
CACYBP
Alternative Names
CacyBP antibody; Calcyclin binding protein antibody; Calcyclin-binding protein antibody; CYBP_HUMAN antibody; GIG 5 antibody; GIG5 antibody; Growth inhibiting gene 5 antibody; Growth inhibiting gene 5 protein antibody; hCacyBP antibody; MGC87971 antibody; PNAS 107 antibody; PNAS107 antibody; RP1 102G20.6 antibody; S100A6 binding protein antibody; S100A6-binding protein antibody; S100A6BP antibody; Siah-interacting protein antibody; SIP antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Calcyclin-binding protein (2-228AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Gene References into Functions
  1. CacyBP expression is regulated by E2F1, EGR1, and CREB transcription factors in colorectal cancer HCT116 cells. PMID: 29197151
  2. Results suggest that CacyBP/SIP plays an important role in inhibiting glioma cell migration and invasion through promoting the degradation of cytoplasmic p27. PMID: 29024247
  3. Data show that S100 calcium binding protein A6 (S100A6) is required for the Ca2+-dependent nuclear translocation of calcyclin binding protein (CacyBP/SIP) in colon cancer SW480 cells. PMID: 29534068
  4. CacyBP/SIP nuclear localization, dependent on S100 protein, suppresses gastric cancer tumorigenesis through beta-catenin degradation and the dephosphorylation of ERK1/2 during the G2 phase. PMID: 29099417
  5. Our data have shown for the first time the regulation of CacyBP/SIP gene expression by NFAT1. Since NFAT transcription factors are involved in processes related to immune response, these results indicate potential involvement of CacyBP/SIP in the immune system. PMID: 28526484
  6. These results suggest that CacyBP/SIP may be promoting growth of colon cancer cells by enhancing ubiquitin-mediated degradation of p27kip1. PMID: 28196083
  7. The biological characteristics and target proteins of CacyBP/SIP and its exact role in various cancers are discussed. Review. PMID: 26873490
  8. CacyBP/SIP nuclear translocation contributes to the proliferation of gastric cancer cells, and CacyBP/SIP exerts this effect, at least in part, by stimulating ubiquitin-mediated degradation of p27Kip1. PMID: 27099442
  9. CacyBP/SIP plays an important role in inhibiting apoptosis of glioma cells which might be mediated by ERK1/2 signaling pathway. PMID: 26825673
  10. CacyBP/SIP is a useful indicator of dis processes in Chronic Lymphocytic Leukemia (CLL) and plays an important role in sustaining the balance of cell proliferation and apoptosis. PMID: 26603518
  11. CacyBP/SIP nuclear translocation promotes the proliferation and cell cycle progression of gastric cancer cells. PMID: 25110433
  12. Overexpression of CacyBP is associated with glioma. PMID: 24740456
  13. This study presents CacyBP as a promising candidate biomarker for colorectal cancer (CRC) metastasis and also sheds light on the underlying molecular mechanism by which CacyBP promotes CRC metastasis. PMID: 23543800
  14. CacyBP enhances multidrug resistance of pancreatic cancer cells by regulation of P-gp and Bcl-2. PMID: 23463283
  15. These findings reveal a novel function for SNRK in the regulation of colon cancer cell proliferation and beta-catenin signaling. PMID: 22874833
  16. different activity of CacyBP/SIP in neuroblastoma NB2a and colon cancer HCT116 cells might affect the ERK1/2 pathway in the differentiation or proliferation processes PMID: 22480271
  17. new insight into the interaction between S100 proteins and CacyBP/SIP PMID: 22295074
  18. Data show that CacyBP/SIP might develop into another possible therapeutic target. PMID: 21268134
  19. Poor cellular differentiation, lymph node invasion, and clinicopathological staging in breast cancer were associated with CacyBP/SIP expression. PMID: 20585948
  20. CacyBP/SIP exhibits a phosphatase activity toward ERK1/2 kinases while its E217K mutant does not. PMID: 21110948
  21. CACYBP is associated with acute lung injury in mice PMID: 21297076
  22. CacyBP regulation of COX-2 expression may play an important role in human breast carcinogenesis PMID: 20878073
  23. investigation of interaction with Siah1 PMID: 12421809
  24. the translocation of CacyBP during the retinoic acid-induced differentiation of neuroblastoma SH-SY5Y cells suggested that this protein might play a role in neuronal differentiation PMID: 12895292
  25. SIP engages Siah1 by means of two elements, both of which are required for mediating beta-catenin destruction in cells PMID: 16085652
  26. Taken together, our work showed that CacyBP/SIP, as a novel down-regulated gene in renal cell carcinoma, suppressed proliferation and tumorigenesis of renal cancer cells. PMID: 17400182
  27. CacyBP/SIP may be a potential inhibitor of cell growth and invasion in the gastric cancer cell, at least in part through the effect on beta-catenin protein expression and transcriptional activation of Tcf/LEF PMID: 18171983
  28. The first study on the CacyBP/SIP expression pattern in a broad range of human normal and tumor tissues. PMID: 18443365
  29. CacyBP/SIP protein might play an important role in the process of pancreatic carcinogenesis and high-level CacyBP/SIP expression might be related to the malignant potential of pancreatic cancer. PMID: 18765951

Show More

Hide All

Subcellular Location
Nucleus. Cytoplasm. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
Database Links

HGNC: 30423

OMIM: 606186

KEGG: hsa:27101

STRING: 9606.ENSP00000356652

UniGene: Hs.508524

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*