CACYBP Antibody

1. CacyBP expression is regulated by E2F1, EGR1, and CREB transcription factors in colorectal cancer HCT116 cells. PMID: 29197151
2. Results suggest that CacyBP/SIP plays an important role in inhibiting glioma cell migration and invasion through promoting the degradation of cytoplasmic p27. PMID: 29024247
3. Data show that S100 calcium binding protein A6 (S100A6) is required for the Ca2+-dependent nuclear translocation of calcyclin binding protein (CacyBP/SIP) in colon cancer SW480 cells. PMID: 29534068
4. CacyBP/SIP nuclear localization, dependent on S100 protein, suppresses gastric cancer tumorigenesis through beta-catenin degradation and the dephosphorylation of ERK1/2 during the G2 phase. PMID: 29099417
5. Our data have shown for the first time the regulation of CacyBP/SIP gene expression by NFAT1. Since NFAT transcription factors are involved in processes related to immune response, these results indicate potential involvement of CacyBP/SIP in the immune system. PMID: 28526484
6. These results suggest that CacyBP/SIP may be promoting growth of colon cancer cells by enhancing ubiquitin-mediated degradation of p27kip1. PMID: 28196083
7. The biological characteristics and target proteins of CacyBP/SIP and its exact role in various cancers are discussed. Review. PMID: 26873490
8. CacyBP/SIP nuclear translocation contributes to the proliferation of gastric cancer cells, and CacyBP/SIP exerts this effect, at least in part, by stimulating ubiquitin-mediated degradation of p27Kip1. PMID: 27099442
9. CacyBP/SIP plays an important role in inhibiting apoptosis of glioma cells which might be mediated by ERK1/2 signaling pathway. PMID: 26825673
10. CacyBP/SIP is a useful indicator of dis processes in Chronic Lymphocytic Leukemia (CLL) and plays an important role in sustaining the balance of cell proliferation and apoptosis. PMID: 26603518
11. CacyBP/SIP nuclear translocation promotes the proliferation and cell cycle progression of gastric cancer cells. PMID: 25110433
12. Overexpression of CacyBP is associated with glioma. PMID: 24740456
13. This study presents CacyBP as a promising candidate biomarker for colorectal cancer (CRC) metastasis and also sheds light on the underlying molecular mechanism by which CacyBP promotes CRC metastasis. PMID: 23543800
14. CacyBP enhances multidrug resistance of pancreatic cancer cells by regulation of P-gp and Bcl-2. PMID: 23463283
15. These findings reveal a novel function for SNRK in the regulation of colon cancer cell proliferation and beta-catenin signaling. PMID: 22874833
16. different activity of CacyBP/SIP in neuroblastoma NB2a and colon cancer HCT116 cells might affect the ERK1/2 pathway in the differentiation or proliferation processes PMID: 22480271
17. new insight into the interaction between S100 proteins and CacyBP/SIP PMID: 22295074
18. Data show that CacyBP/SIP might develop into another possible therapeutic target. PMID: 21268134
19. Poor cellular differentiation, lymph node invasion, and clinicopathological staging in breast cancer were associated with CacyBP/SIP expression. PMID: 20585948
20. CacyBP/SIP exhibits a phosphatase activity toward ERK1/2 kinases while its E217K mutant does not. PMID: 21110948
21. CACYBP is associated with acute lung injury in mice PMID: 21297076
22. CacyBP regulation of COX-2 expression may play an important role in human breast carcinogenesis PMID: 20878073
23. investigation of interaction with Siah1 PMID: 12421809
24. the translocation of CacyBP during the retinoic acid-induced differentiation of neuroblastoma SH-SY5Y cells suggested that this protein might play a role in neuronal differentiation PMID: 12895292
25. SIP engages Siah1 by means of two elements, both of which are required for mediating beta-catenin destruction in cells PMID: 16085652
26. Taken together, our work showed that CacyBP/SIP, as a novel down-regulated gene in renal cell carcinoma, suppressed proliferation and tumorigenesis of renal cancer cells. PMID: 17400182
27. CacyBP/SIP may be a potential inhibitor of cell growth and invasion in the gastric cancer cell, at least in part through the effect on beta-catenin protein expression and transcriptional activation of Tcf/LEF PMID: 18171983
28. The first study on the CacyBP/SIP expression pattern in a broad range of human normal and tumor tissues. PMID: 18443365
29. CacyBP/SIP protein might play an important role in the process of pancreatic carcinogenesis and high-level CacyBP/SIP expression might be related to the malignant potential of pancreatic cancer. PMID: 18765951

Show More

Hide All

HGNC: 30423

OMIM: 606186

KEGG: hsa:27101

STRING: 9606.ENSP00000356652

UniGene: Hs.508524