CADM2 Antibody

Code CSB-PA003005
Size US$100
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  • Western Blot analysis of HepG2 cells using IGSF4D Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
Alternative Names
CADM2 antibody; CADM2_HUMAN antibody; Cell adhesion molecule 2 antibody; IgSF4D antibody; Immunoglobulin superfamily member 4D antibody; NECL 2 antibody; Necl 3 antibody; NECL-3 antibody; NECL2 antibody; Necl3 antibody; Nectin like protein 3 antibody; Nectin-like protein 3 antibody; synCAM 2 antibody; synCAM2 antibody
Raised in
Species Reactivity
Synthesized peptide derived from the Internal region of Human IGSF4D.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.
Gene References into Functions
  1. Ectopic expression of CADM2 counteracted the promoting effect of miR-146a on cell proliferation, migration, invasion, and the epithelial-mesenchymal transition process. PMID: 30184528
  2. CADM2 SNPs were associated with lifetime cannabis use, but the association did not reach genome-wide significance. [Meta-Analysis] PMID: 27023175
  3. A significant association was observed for the single-nucleotide polymorphism (SNP) rs17518584 and in the joint discovery and replication meta-analysis in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST. PMID: 25869804
  4. In the absence of SynCAMs, selective axon-axon interactions are perturbed resulting in aberrant pathfinding of sensory axons. PMID: 25335893
  5. Cox regression analysis indicated that CADM2 expression level, tumor size, tumor number, vascular invasion, HBsAg were independent risk factors for HCC recurrence PMID: 24240726
  6. Thus, we conclude that CADM2 functions as a novel tumor suppressor and may serve as a potential therapeutic target for human renal cell carcinoma. PMID: 23643812
  7. The results indicated that CADM2 is one of the pathogenic factors for psoriasis. PMID: 21864505
  8. Its expression is regulated in part by promoter methylation and implicates CADM-2 as a previously unrecognized tumor suppressor gene in a proportion of human prostate cancers. PMID: 21062931
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19861958

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Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons.
Protein Families
Nectin family
Database Links

HGNC: 29849

OMIM: 609938

KEGG: hsa:253559

STRING: 9606.ENSP00000384193

UniGene: Hs.164578

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