CARMIL1 Antibody

Datasheet

Code	CSB-PA713356LA01HU
Size	US$166
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Image	Immunofluorescence staining of HepG2 cells with CSB-PA713356LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CARMIL1 Polyclonal antibody

Uniprot No.

Q5VZK9

Target Names

CARMIL1

Alternative Names

Acan 125 antibody; Capping protein; Arp2/3; and myosin I linker antibody; CARMIL homolog antibody; leucine rich repeat containing 16 antibody; Leucine-rich repeat-containing protein 16A antibody; LR16A_HUMAN antibody; Lrrc16 protein antibody; LRRC16A antibody; p116 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human F-actin-uncapping protein LRRC16A protein (1184-1295AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CARMIL1 Antibody (Product code: CSB-PA713356LA01HU) is Non-conjugated. For CARMIL1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA713356LB01HU	CARMIL1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA713356LC01HU	CARMIL1 Antibody, FITC conjugated
Biotin	CSB-PA713356LD01HU	CARMIL1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration.

Gene References into Functions

A novel genetic variant in leucine-rich repeat-containing 16A (LRRC16A) has been associated with reduced ARDS risk. PMID: 27768389
LRRC16A plays a role in adult respiratory distress syndrome pathophysiology by interacting with, and being mediated through, platelets. PMID: 25254322
shown for the first time that CARMIL/LRRC16A was associated with gout, which could be due to urate transportsome failure PMID: 24318514
The results also suggest that the ability of CARMIL1 to inhibit CP in cells may be regulated. PMID: 23904264
Data suggest that CARMIL promotes uncapping by binding to a freely accessible site on Capping protein (CP) bound to a filament barbed end and inducing a change in the conformation of the actin-binding surface of CP. PMID: 22411988
The two CARMIL isoforms are both important for cell migration, but they have distinct functions.[CARMIL1, CARMIL2] PMID: 19846667

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Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium.

Protein Families

CARMIL family

Tissue Specificity

Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.

Database Links

HGNC: 21581

OMIM: 609593

KEGG: hsa:55604

STRING: 9606.ENSP00000331983

UniGene: Hs.649550

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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