CASC3 Antibody

Datasheet

Code	CSB-PA004535GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

O15234

Target Names

CASC3

Alternative Names

Barentsz antibody; Barentsz protein antibody; Btz antibody; Cancer susceptibility candidate 3 antibody; Cancer susceptibility candidate gene 3 protein antibody; CASC3 antibody; CASC3_HUMAN antibody; Metastatic lymph node 51 antibody; Metastatic lymph node gene 51 protein antibody; Metastatic lymph node protein 51 antibody; MLN 51 antibody; MLN 51 protein antibody; MLN51 antibody; Protein barentsz antibody; Protein CASC3 antibody; Protein MLN 51 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human CASC3

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer.

Gene References into Functions

High CASC3 expression is associated with hepatocellular carcinoma. PMID: 27029030
MLN51, alone or as part of the EJC, interacts directly with the pivotal eukaryotic translation initiation factor eIF3 PMID: 23530232
MLN51 is a key factor in fibroblast-like synoviocyte hyperplasia of rheumatoid arthritis patients. PMID: 21327427
data demonstrate that metastatic lymph node(MLN)51 protein associates with exon junction complex in the nucleus and remains stably associated with messenger RNA in the cytoplasm PMID: 15166247
MLN51 is recruited into cytoplasmic aggregates known as stress granules (SGs) together with the SG-resident proteins. PMID: 17652158

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Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Cytoplasm, Stress granule. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cell projection, dendrite.

Protein Families

CASC3 family

Tissue Specificity

Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers.

Database Links

HGNC: 17040

OMIM: 606504

KEGG: hsa:22794

STRING: 9606.ENSP00000264645

UniGene: Hs.743287

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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