CCNO Antibody

Datasheet

Code	CSB-PA004831LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA004831LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA004831LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA004831LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CCNO Polyclonal antibody

Uniprot No.

P22674

Target Names

CCNO

Alternative Names

CCNO antibody; CCNO_HUMAN antibody; CCNU antibody; Cyclin domain containing antibody; Cyclin like uracil DNA glycosylase antibody; Cyclin O antibody; Cyclin U antibody; Cyclin-O antibody; DGU antibody; EC 3.2.2. antibody; UDG2 antibody; UNG2 antibody; Uracil DNA glycolylase 2 antibody; Uracil DNA glycosylase cyclin like antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cyclin-O protein (1-257AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CCNO Antibody (Product code: CSB-PA004831LA01HU) is Non-conjugated. For CCNO Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA004831LB01HU	CCNO Antibody, HRP conjugated	ELISA
FITC	CSB-PA004831LC01HU	CCNO Antibody, FITC conjugated
Biotin	CSB-PA004831LD01HU	CCNO Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.

Gene References into Functions

This study presents the crystal structure of the DDB1-DCAF1-HIV-1-Vpr-uracil-DNA glycosylase (cyclin U) complex. PMID: 27571178
CCNO is mutated more frequently than expected from the rare previous clinical case reports, leads to severe clinical manifestations, and should therefore be considered an important differential diagnosis of mucociliary clearance disorders. PMID: 26777464
CCNO mutations have a role in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia PMID: 24747639
This publication corrected the mistaken attribution of uracil DNA glycosylase activity to this gene. PMID: 8419333
This publication initially attributed 'uracil-DNA glycosylase' activity to this gene and named it UNG2, but a later publication (PubMed ID: 8419333) more correctly identified UNG2/CCNO as a member of the cyclin protein family. PMID: 2001396

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Involvement in disease

Ciliary dyskinesia, primary, 29 (CILD29)

Subcellular Location

Cytoplasm. Nucleus, nucleolus.

Protein Families

Cyclin family

Tissue Specificity

Present in respiratory cells (at protein level).

Database Links

HGNC: 18576

OMIM: 607752

KEGG: hsa:10309

STRING: 9606.ENSP00000282572

UniGene: Hs.3041

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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