CCT8 Antibody

Datasheet

Code	CSB-PA004873LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Jurkat whole cell lysate, Raji whole cell lysate, Hela whole cell lysate, HEK293 whole cell lysate, NIH/3T3 whole cell lysate, K562 whole cell lysate All lanes: CCT8 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 60, 58, 52 kDa Observed band size: 60 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA004873LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA004873LA01HU at dilution of 1:100 Immunofluorescent analysis of MCF-7 cells using CSB-PA004873LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CCT8 Polyclonal antibody

Uniprot No.

P50990

Target Names

CCT8

Alternative Names

CCT8 antibody; C21orf112 antibody; CCTQ antibody; KIAA0002 antibody; T-complex protein 1 subunit theta antibody; TCP-1-theta antibody; CCT-theta antibody; Chaperonin containing T-complex polypeptide 1 subunit 8 antibody; Renal carcinoma antigen NY-REN-15 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human T-complex protein 1 subunit theta protein (224-491AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CCT8 Antibody (Product code: CSB-PA004873LA01HU) is Non-conjugated. For CCT8 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA004873LB01HU	CCT8 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004873LC01HU	CCT8 Antibody, FITC conjugated
Biotin	CSB-PA004873LD01HU	CCT8 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.

Gene References into Functions

Study demonstrated that CCT8 expression is widely upregulated in esophageal squamous cell carcinoma (ESCC), and enhanced the migration and invasion of ESCC cells, indicating that ectopic CCT8 expression contributes to the highly aggressive nature of ESCC probably by increasing alpha-actin and beta-tubulin expression. PMID: 29620162
Ectopic expression of CCT8 also ameliorates the age-associated demise of proteostasis and corrects proteostatic deficiencies in worm models of Huntington's disease. PMID: 27892468
data suggest that the GRP94/CCT8/c-Jun/EMT signaling cascade might be a new therapeutic target for HCC PMID: 26718209
showed that high CCT8 protein expression might be related to poor outcome of glioma PMID: 26304164

Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.

Protein Families

TCP-1 chaperonin family

Database Links

HGNC: 1623

OMIM: 617786

KEGG: hsa:10694

STRING: 9606.ENSP00000286788

UniGene: Hs.125113

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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