CD300A Antibody

Code CSB-PA887023ESR1HU
Size US$166
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Image
  • Western blot
    All lanes: CNTN4 antibody IgG at 2.22μg/ml + Mouse kidney tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 34, 21, 12, 17 kDa
    Observed band size: 34 kDa

  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA887023ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CD300A Polyclonal antibody
Uniprot No.
Target Names
CD300A
Alternative Names
CD300 antigen-like family member A antibody; CD300a antibody; CD300a antigen antibody; CD300a molecule antibody; CLM-8 antibody; CLM8_HUMAN antibody; CMRF 35 H9 antibody; CMRF-35-H9 antibody; CMRF35-H antibody; CMRF35-H9 antibody; CMRF35-like molecule 8 antibody; CMRF35H antibody; CMRF35H leukocyte immunoglobulin like receptor antibody; CMRF35H9 antibody; IgSF12 antibody; Immunoglobulin superfamily member 12 antibody; Inhibitory receptor protein 60 antibody; IRC1 antibody; IRC1/IRC2 antibody; IRC2 antibody; IRp60 antibody; Leukocyte membrane antigen antibody; Mast cell derived paired immunoglobulin like receptor 1 antibody; NK inhibitory receptor antibody; Polymeric immunoglobulin receptor 4 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human CMRF35-like molecule 8 protein (18-180AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6.
Gene References into Functions
  1. Results provide an insight into the novel set of paired receptors CD300a and CD300c that are distinctively expressed on CD56(bright) natural killers (NK) cells with varied effector functions and show there differential binding to their ligands phosphatidylethanolamine and phosphatidylserine (PS) resulting in their differential ability to affect CD56(bright) NK cell functions. PMID: 27040328
  2. High CD300A expression is associated with diffuse large B-cell lymphoma. PMID: 26435477
  3. US3 protein kinase of pseudorabies virus triggers the binding of the inhibitory natural killer cell receptor CD300a to the surface of the infected cell, and protects of virus infected cells against natural killer cell-mediated lysis. PMID: 26581992
  4. Overall, these data indicate that CD300a is a novel Dengue virus binding receptor that recognizes phosphatidylethanolamine and phosphatidylserine present on virions and enhance infection. PMID: 26468529
  5. Data show that peroxisome proliferator activator receptor delta (PPARdelta/beta) directly regulates CD300a protein in macrophages. PMID: 24958459
  6. CD300a induction by the hypoxic environment represents a mechanism of regulation of monocyte/macrophage pro-inflammatory responses at pathologic sites PMID: 24131792
  7. interaction with phosphatidylserines inhibits IgE/FcepsilonRI-dependent anaphylactic basophil degranulation PMID: 24815424
  8. The inhibitory receptor CD300a is regulator of monocytes transendothelial migration. PMID: 24058511
  9. SHP-1, but not SHP-2 or the src homology 2 domain containing inositol 5' phosphatase SHIP, was utilized by CD300a for its inhibitory activity. These studies provide new insights into the function of CD300a in tuning T and B cell responses. PMID: 22537350
  10. CD300a is expressed on human peripheral blood basophils and rapidly up-regulated upon cross-linking of IgE/Fc-epsilon-RI and suppresses anaphylactic degranulation. PMID: 22173928
  11. our results indicate that phosphatidylethanolamine and phosphatidylserine are ligands for CD300a, and that this interaction plays an important role in regulating the removal of dead cells. PMID: 22302738
  12. These results indicated that CD300a is a new phosphatidylserine receptor. PMID: 22185693
  13. CD300a blocked TLR4-mediated and TLR9-mediated expression of pro-inflammatory mediators without affecting TLR3-mediated events. PMID: 22043923
  14. Down-regulation of CD300a is associated with HIV infection. PMID: 21482706
  15. CD300a is an inhibitory receptor expressed by human natural killer (NK) cells, but surprisingly, not all NK clones are inhibited in a CD300a-dependent manner. PMID: 20656921
  16. CD300a(+) human Th1 cells tend to be polyfunctional and after stimulation up-regulate Eomes. PMID: 20498708
  17. CMRF35A and CMRF35H have roles in immunoglobulin signaling; CMRF35H is an inhibitory molecule [review] PMID: 12456026
  18. IRp60 is constitutively expressed on mast cells but is down-regulated by eosinophil major basic protein and eosinophil-derived neurotoxin. Cross-linking of IRp60 led to inhibition of IgE-induced degranulation and stem cell factor-mediated survival PMID: 16339535
  19. Human neutrophils from peripheral blood express the ITIM containing CD300a (also known as IRp60 and CMRF-35H) receptor. Co-ligation of CD300a with (FcgammaRIIa) activation receptor inhibited CD32a mediated signalling. PMID: 17588661
  20. CD300a as a novel regulator of Kit in human MC and suggest roles for this receptor as a suppressor of Kit signaling in MC-related disorders. PMID: 18424727

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
CD300 family
Tissue Specificity
Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.
Database Links

HGNC: 19319

OMIM: 606790

KEGG: hsa:11314

STRING: 9606.ENSP00000353259

UniGene: Hs.9688

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