CD300LB Antibody

Code CSB-PA004919LA01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CD300LB Polyclonal antibody
Uniprot No.
Target Names
CD300LB
Alternative Names
CD300LB antibody; CD300B antibody; CLM7 antibody; CMRF35A2 antibody; IREM3 antibody; LMIR5 antibody; TREM5 antibody; UNQ2530/PRO6029CMRF35-like molecule 7 antibody; CLM-7 antibody; CD300 antigen-like family member B antibody; CMRF35-A2 antibody; Immune receptor expressed on myeloid cells 3 antibody; IREM-3 antibody; Leukocyte mono-Ig-like receptor 5 antibody; Triggering receptor expressed on myeloid cells 5 antibody; TREM-5 antibody; CD antigen CD300b antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human CMRF35-like molecule 7 protein (18-151AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CD300LB Antibody (Product code: CSB-PA004919LA01HU) is Non-conjugated. For CD300LB Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA004919LB01HU CD300LB Antibody, HRP conjugated ELISA
FITC CSB-PA004919LC01HU CD300LB Antibody, FITC conjugated
Biotin CSB-PA004919LD01HU CD300LB Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.
Gene References into Functions
  1. this paper identified CD300b as an lipopolysaccharide-recognizing receptor that regulated TLR4 signaling PMID: 27261276
  2. CD300LB expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
  3. CD300 molecules are all expressed by DC; CD300b, d, e and f are restricted to different subpopulations of the myeloid DC lineage. They have been shown to regulate DC function both in vitro and in vivo. PMID: 23072861
  4. CD300b defines a nonclassical Ig receptor able to trigger signals by coupling distinct mediators and thus initiating different signaling pathways PMID: 16920917
  5. although both mouse and human LMIR5 play activatory roles in innate immunity cells, the functions of LMIR5 were differentially regulated in mouse versus human cells. PMID: 17928527

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
CD300 family
Tissue Specificity
Expressed exclusively in myeloid lineages.
Database Links

HGNC: 30811

OMIM: 610705

KEGG: hsa:124599

STRING: 9606.ENSP00000376397

UniGene: Hs.313343

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