CDCA7L Antibody

Datasheet

Code	CSB-PA850301LA01HU
Size	US$166
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Image	IHC image of CSB-PA850301LA01HU diluted at 1:400 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA850301LA01HU diluted at 1:400 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CDCA7L Polyclonal antibody

Uniprot No.

Q96GN5

Target Names

CDCA7L

Alternative Names

c Myc Interacting protein JPO2 antibody; CDA7L_HUMAN antibody; Cdca7l antibody; Cell division cycle-associated 7-like protein antibody; DKFZp762L0311 antibody; HR1 antibody; JPO2 antibody; Protein JPO2 antibody; R1 antibody; RAM2 antibody; Transcription factor RAM2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cell division cycle-associated 7-like protein (14-167AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CDCA7L Antibody (Product code: CSB-PA850301LA01HU) is Non-conjugated. For CDCA7L Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA850301LB01HU	CDCA7L Antibody, HRP conjugated	ELISA
FITC	CSB-PA850301LC01HU	CDCA7L Antibody, FITC conjugated
Biotin	CSB-PA850301LD01HU	CDCA7L Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.

Gene References into Functions

Suppression of CDCA7L limits multiple myeloma proliferation through apoptosis. PMID: 27882933
We identify the Myc-interacting protein JPO2 and its partner binding protein LEDGF/p75 as critical modulators of PI3K/AKT signaling and metastasis in medulloblastoma PMID: 27013196
common LEDGF/p75 interaction interface shared by JPO2, PogZ, MLL1, IWS1 and HIV IN PMID: 26245978
The data are consistent with the rs4487645-CDCA7L loci being responsible for the chromosome 7p11.2 association with multiple myeloma risk, probably exerting its effects through an extended pathway involving IRF4 and MYC. PMID: 25480495
Data indicate that JPO2 and LEDGF/p75 interact directly and specifically in vivo through the specific interaction domain of JPO2 and the C-terminal domain of LEDGF/p75. PMID: 24634210
CDCA7L was able to activate the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting HCC progression. PMID: 24141559
Reduction in R1 repressor protein correlates significantly with an increase (approximately 40%) in monoamine oxidase A protein levels within the major depressive disorder groups compared with controls. PMID: 21654740
monoamine oxidase A activation of glucocorticoids and androgens is regulated differently by R1 and Sp1 PMID: 16728402
demonstrates the functions of MAO A and its repressor R1(RAM2/CDCA7L/JPO2) in apoptotic signaling pathways PMID: 16829576
Over-expression of JPO2 resulted in a modest but reproducible inhibition of HIV-1 replication, consistent with competition between integrase and JPO2 for binding to LEDGF/p75 PMID: 17669426

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Subcellular Location

Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.

Tissue Specificity

Ubiquitous. Overexpressed in medulloblastoma.

Database Links

HGNC: 30777

OMIM: 609685

KEGG: hsa:55536

STRING: 9606.ENSP00000383986

UniGene: Hs.744069

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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