CDH4 Antibody

Code CSB-PA219157
Size US$166
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Image
  • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: CSB-PA219157(CDH4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details

Uniprot No.
Target Names
CDH4
Alternative Names
CDH4; Cadherin-4; Retinal cadherin; R-CAD; R-cadherin
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide of Human CDH4
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
Gene References into Functions
  1. Low expression of CDH4 is associated with lung cancer. PMID: 28095912
  2. Further knockdown R-cadherin in linc-cdh4-2 stably overexpressed cells, could significantly upregulate the protein levels of RAC1 and improve the cell migration and invasion abilities. Taken together, the novel linc-cdh4-2 may negatively regulate the motility of the HCC cells through targeting R-cadherin-RAC1 signaling pathway. PMID: 27765630
  3. Data show that low expression of R-cadherin is associated with the poor prognosis in gastric cancer. PMID: 27029387
  4. P-cadherin expression correlated with tumor progression and could be an independent predictor for bladder cancer survival. PMID: 24429027
  5. R-cadherin adherens junction formation facilitates a mesenchymal to epithelial-like transition in MDA-MB-231 cells. PMID: 22820501
  6. Findings identify an important role of CHD4 in controlling homologous recombination repair to maintain genome stability and establish the potential therapeutic implications of targeting CHD4 deficiency in tumors. PMID: 22219182
  7. a novel putative tumor suppressor gene that can be frequently and tumor-specifically inactivated by its promoter methylation in nasopharyngeal carcinoma PMID: 21665361
  8. R-cadherin induces cell motility when expressed in epithelial cells, and this increased motility is dependent upon Rho GTPase activity. PMID: 15143071
  9. CDH4 may act as a tumor suppressor gene in human gastrointestinal tumors and can potentially be used as an early diagnostic marker for gastrointestinal tumorigenesis PMID: 15548679

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed mainly in brain but also found in other tissues.
Database Links

HGNC: 1763

OMIM: 603006

KEGG: hsa:1002

STRING: 9606.ENSP00000353656

UniGene: Hs.473231

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