CDK11A Antibody

Datasheet

Code	CSB-PA05204A0Rb
Size	US$166
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Image	Western Blot Positive WB detected in: PC-3 whole cell lysate, Rat kidney tissue All lanes: CDK11A antibody at 4µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 92, 91, 46, 19, 63, 50 kDa Observed band size: 92 kDa IHC image of CSB-PA05204A0Rb diluted at 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescent analysis of Hela cells using CSB-PA05204A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CDK11A Polyclonal antibody

Uniprot No.

Q9UQ88

Target Names

CDK11A

Alternative Names

CD11A_HUMAN antibody; CDC2L2 antibody; CDC2L3 antibody; CDK11 antibody; CDK11 p110 antibody; CDK11 p46 antibody; CDK11 p58 antibody; CDK11A antibody; Cell division cycle 2 like 2 (PITSLRE proteins) antibody; Cell division cycle 2-like protein kinase 2 antibody; Cell division protein kinase 11A antibody; Cyclin-dependent kinase 11A antibody; Galactosyltransferase-associated protein kinase p58/GTA antibody; p58GTA antibody; PITSLRE antibody; PITSLRE B antibody; PITSLRE protein kinase beta antibody; PITSLRE serine/threonine-protein kinase CDC2L2 antibody; PITSLREB antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Cyclin-dependent kinase 11A protein (5-216AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CDK11A Antibody (Product code: CSB-PA05204A0Rb) is Non-conjugated. For CDK11A Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA05204B0Rb	CDK11A Antibody, HRP conjugated	ELISA
FITC	CSB-PA05204C0Rb	CDK11A Antibody, FITC conjugated
Biotin	CSB-PA05204D0Rb	CDK11A Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:500-1:1000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.

Gene References into Functions

CDK11 has a role in human cancers [review] PMID: 27049727
Observational study of gene-disease association. (HuGE Navigator) PMID: 20508983
demonstrates that CDK11(p46) directly interacts with RanBPM in vitro and in human cells PMID: 14511641
the PITSLRE IRES interacts with the Unr protein, which is more prominently expressed at the G2/M stage of the cell cycle PMID: 15330758
CDK11 kinases could be regulated by interaction with 14-3-3 proteins during cell cycle and apoptosis PMID: 15883043
CDK11(p58) is a new interacting protein and a novel regulator of histone acetyltransferase (HAT) HBO1. PMID: 15963510
CDK11p60 can contribute to apoptosis by direct signalling at the mitochondria, thereby amplifying Fas-induced apoptosis in melanoma cells. PMID: 16004605
These findings suggest that CDK11 may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity. PMID: 16039607
mitotic CDK11(p58) isoform, but not the CDK11(p110) isoform, associates with mitotic centrosomes PMID: 16462731
CDC2L2 gene may contribute to the susceptibility of type 2 diabetes in the northern Han Chinese population. PMID: 17177267
findings show that, in addition to playing a role in spindle formation and structure, CDK11(p58) is also required for sister chromatid cohesion and the completion of mitosis PMID: 17606997
These data identified a new negative regulatory protein of ERalpha and provided a new pathway by which CDK11(p58) negatively regulated cells. PMID: 19122208
Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis. PMID: 19245811
study identified p21 activated kinase 1 (PAK1) as a new CDK11(p58) substrate; mapped a new phosphorylation site of Ser174 on PAK1; results indicated PAK1 may serve as a downstream effector of CDK11(p58) during mitosis progression PMID: 19520772
Observational study of gene-disease association. (HuGE Navigator) PMID: 17177267

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily

Tissue Specificity

Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.

Database Links

HGNC: 1730

OMIM: 116951

KEGG: hsa:728642

UniGene: Hs.651228

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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