CHRM4 Antibody

1. the association of the African-specific CHRM4 SNP with cocaine dependence survived correction for multiple testing PMID: 27269905
2. This study identify suppression of the PVHSIM1-->PAGvl/DR circuit connection as sufficient to induce overeating behavior. PMID: 24768300
3. Data indicate that compounds derived from VU0152100 showed M4 muscarinic receptor (M4 mAChR) direct agoinst properties. PMID: 24074052
4. The data of this study suggested that the rs2067482 polymorphism may help to predict susceptibility to schizophrenia and/or therapeutic responsiveness. PMID: 23490763
5. Use of HM4- and green fluorescent protein-expressing trangenic mice as tissue donors in cell-based therapy validates a rodent model of Huntington disease. PMID: 21295605
6. analysis of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor PMID: 20406819
7. relative to other muscarinic receptor subtypes, the M(4) receptor could be the subtype which is selectively compromised in Alzeheimer's disease PMID: 12505680
8. M4 increases expression of "migratory" integrins; M4 effects resulted from inhibition of the inhibitory pathway involving the adenylyl cyclase-cyclic AMP-protein kinase A pathway PMID: 15263021
9. In progressive supranuclear palsy: there were no changes in M4 muscarinic receptor density PMID: 18282687
10. Regions in i3 including Leu272-Arg338 and Val373-Ala393 are involved in internalization of the M4 receptor; the region including Val373-Ala393 is indispensable for its recycling, whereas the other regions are dispensable for internalization and recycling. PMID: 18337477

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HGNC: 1953

OMIM: 118495

KEGG: hsa:1132

STRING: 9606.ENSP00000409378

UniGene: Hs.248100