CHST10 Antibody

Code CSB-PA005403LA01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CHST10 Polyclonal antibody
Uniprot No.
Target Names
CHST10
Alternative Names
CHST10; Carbohydrate sulfotransferase 10; HNK-1 sulfotransferase; HNK-1ST; HNK1ST; HuHNK-1ST
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Carbohydrate sulfotransferase 10 protein (28-356AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CHST10 Antibody (Product code: CSB-PA005403LA01HU) is Non-conjugated. For CHST10 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA005403LB01HU CHST10 Antibody, HRP conjugated ELISA
FITC CSB-PA005403LC01HU CHST10 Antibody, FITC conjugated
Biotin CSB-PA005403LD01HU CHST10 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis.
Gene References into Functions
  1. novel role for HNK-1ST as a tumor suppressor controlling the functional glycans on alpha-DG and the importance of sulfate transfer in the glycosylation of alpha-DG. PMID: 22801424
  2. These results suggest that HNK-1ST is involved in 3-O-sulfation of the terminal GlcA of the linkage tetrasaccharide which acts as an inhibitory signal for the initiation of chondroitin sulfate chain biosynthesis on thrombomodulin. PMID: 22020094
  3. HNK-1ST may be responsible for regulating the sorting of alpha- and beta-TM. PMID: 21828042
  4. identification of a novel member of HNK-1 family of sulfotransferases PMID: 12080076
  5. We show that CHST10 is also regulated by RARgamma in a significant subset of human melanoma cells, and three-dimensional cell culture migration assays suggest that CHST10 functions as a suppressor of invasiveness, but not proliferation, in these cells PMID: 19470764

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Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein Families
Sulfotransferase 2 family
Tissue Specificity
In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart, pancreas, skeletal muscle, spleen and thymus, and
Database Links

HGNC: 19650

OMIM: 606376

KEGG: hsa:9486

STRING: 9606.ENSP00000264249

UniGene: Hs.516370

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