CHST10 Antibody

Datasheet

Code	CSB-PA877976
Size	US$297
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Image	Western blot analysis of extracts from HuvEc cells, using CHST10 antibody. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CHST10 antibody.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CHST10 Polyclonal antibody

Uniprot No.

O43529

Target Names

CHST10

Alternative Names

CHST10; Carbohydrate sulfotransferase 10; HNK-1 sulfotransferase; HNK-1ST; HNK1ST; HuHNK-1ST

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from internal of Human CHST10.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis.

Gene References into Functions

novel role for HNK-1ST as a tumor suppressor controlling the functional glycans on alpha-DG and the importance of sulfate transfer in the glycosylation of alpha-DG. PMID: 22801424
These results suggest that HNK-1ST is involved in 3-O-sulfation of the terminal GlcA of the linkage tetrasaccharide which acts as an inhibitory signal for the initiation of chondroitin sulfate chain biosynthesis on thrombomodulin. PMID: 22020094
HNK-1ST may be responsible for regulating the sorting of alpha- and beta-TM. PMID: 21828042
identification of a novel member of HNK-1 family of sulfotransferases PMID: 12080076
We show that CHST10 is also regulated by RARgamma in a significant subset of human melanoma cells, and three-dimensional cell culture migration assays suggest that CHST10 functions as a suppressor of invasiveness, but not proliferation, in these cells PMID: 19470764

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Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Protein Families

Sulfotransferase 2 family

Tissue Specificity

In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart, pancreas, skeletal muscle, spleen and thymus, and

Database Links

HGNC: 19650

OMIM: 606376

KEGG: hsa:9486

STRING: 9606.ENSP00000264249

UniGene: Hs.516370

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